[糖尿病患者泪液功能与结膜表面的研究]
[Study of tear function and the conjunctival surface in diabetic patients].
作者信息
Figueroa-Ortiz L C, Jiménez Rodríguez E, García-Ben A, García-Campos J
机构信息
Area de Oftalmo-Biología, Centro de Investigaciones Médico-Sanitarias, Universidad de Málaga, España.
出版信息
Arch Soc Esp Oftalmol. 2011 Apr;86(4):107-12. doi: 10.1016/j.oftal.2010.12.010. Epub 2011 Mar 10.
OBJECTIVES
This study was performed to investigate whether different grades of diabetic retinopathy correlate with tear and ocular surface function in diabetic patients without subjective symptoms of dry eye.
METHODS
A total of 129 eyes of 72 patients without dry eye, assessed using McMonnies questionnaire were recruited to the study. The tear film and ocular surface were evaluated using the Schirmer test, tear film break-up time (BUT), fluorescein and lissamine green staining test, and conjunctival impression cytology. The results were analysed.
RESULTS
A normal Schirmer test and BUT was obtained in 51 and 67% of the eyes of diabetics patients, respectively. Fluorescein and lissamine green staining were negative in 81 and 95% of the eyes. The area and density of goblet cells was 580.46 ± 370 μm(2) and 235.58 ± 109.03 goblets cell/mm(2), respectively.
CONCLUSIONS
Diabetic retinopathy patients without subjective symptoms of dry eye and normal Schirmer and BUT test showed pathological grades of squamous metaplasia.
目的
本研究旨在调查在无干眼主观症状的糖尿病患者中，不同等级的糖尿病视网膜病变是否与泪液及眼表功能相关。
方法
本研究共纳入72例无干眼的患者的129只眼，采用麦克莫尼斯问卷进行评估。使用泪液分泌试验、泪膜破裂时间（BUT）、荧光素和丽丝胺绿染色试验以及结膜印迹细胞学检查对泪膜和眼表进行评估。对结果进行分析。
结果
糖尿病患者分别有51%和67%的眼获得了正常的泪液分泌试验结果和泪膜破裂时间。81%和95%的眼荧光素和丽丝胺绿染色为阴性。杯状细胞的面积和密度分别为580.46±370μm²和235.58±109.03个杯状细胞/mm²。
结论
无干眼主观症状且泪液分泌试验和泪膜破裂时间正常的糖尿病视网膜病变患者表现出鳞状化生的病理分级。
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