德黑兰成年人的冠心病 10 年风险分布和治疗方法的适应证。

Distribution of 10-year risk for coronary heart disease and eligibility for therapeutic approaches among Tehranian adults.

机构信息

Obesity Research Centre, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Public Health. 2011 Jun;125(6):338-44. doi: 10.1016/j.puhe.2011.02.002. Epub 2011 May 14.

DOI:10.1016/j.puhe.2011.02.002

PMID:21570699

Abstract

OBJECTIVES

To establish the distribution of 10-year risk for coronary heart disease (CHD) and eligibility for therapeutic approaches among Tehranian adults within the framework of the Tehran Lipid and Glucose Study (TLGS).

STUDY DESIGN

Cross-sectional study conducted on data from Phase III of the TLGS (12,521 people aged ≥3 years).

METHODS

The modified Framingham algorithm adopted by the National Cholesterol Education Program Adult Treatment Panel III was used to estimate participants' 10-year risk of developing CHD; only participants aged 20-79 years were included. Following the exclusion of subjects without full relevant data, 9483 participants (42.6% men) were enrolled in the final analysis. The distributions of the population needing therapeutic lifestyle changes (TLCs) and additional drug therapy were calculated.

RESULTS

Overall, the mean (standard deviation) age was 43.7 (15.4) years; 44.6 (15.9) for men and 43.0 (14.9) for women. Ten-year risk for CHD of <10%, 10-20% and >20% was observed in 86.0%, 12.0% and 2.0% of participants with at least two risk factors and without CHD or a CHD risk equivalent, respectively. For subjects with less than two risk factors and without CHD or a CHD risk equivalent, these values were 14.0%, 8.3% and 14.7%, respectively; 63.1% of subjects had less than two risk factors. The need for TLCs and additional drug therapy was observed in 12% and 12.5% of subjects, respectively.

CONCLUSIONS

Regarding the estimated 10-year risk for CHD, about one-quarter of Tehranian adults are eligible for therapeutic approaches.

摘要

目的

在德黑兰血脂和血糖研究（TLGS）框架内，确定德黑兰成年人冠心病（CHD）的 10 年风险分布和治疗方法的适应证。

研究设计

这是一项横断面研究，基于 TLGS 第三阶段的数据进行（12521 名年龄≥3 岁的人）。

方法

采用美国国家胆固醇教育计划成人治疗专家组 III 采用的改良 Framingham 算法来估计参与者发生 CHD 的 10 年风险；仅纳入年龄在 20-79 岁的参与者。在排除没有完整相关数据的受试者后，最终有 9483 名（42.6%为男性）参与者纳入最终分析。计算需要治疗生活方式改变（TLCs）和额外药物治疗的人群分布。

结果

总体而言，平均（标准差）年龄为 43.7（15.4）岁；男性为 44.6（15.9）岁，女性为 43.0（14.9）岁。在至少有两个危险因素且没有 CHD 或 CHD 风险等效的参与者中，10 年 CHD 风险<10%、10-20%和>20%分别为 86.0%、12.0%和 2.0%。在危险因素少于两个且没有 CHD 或 CHD 风险等效的受试者中，这些值分别为 14.0%、8.3%和 14.7%；63.1%的受试者危险因素少于两个。TLCs 和额外药物治疗的需求分别为 12%和 12.5%。