Division of Biochemical Pharmacology, Department of Basic Medical Research, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791-0295, Japan.
Fitoterapia. 2011 Sep;82(6):827-33. doi: 10.1016/j.fitote.2011.04.008. Epub 2011 May 4.
The Swertia japonica is used clinically as a remedy for gastrointestinal symptoms in Japan. We examined the effects of a S. japonica and swertiamarin on gastric emptying and gastrointestinal motility in atropine-, dopamine-, and 5-hydroxytryptamine (5-HT)-treated mice. All three preparations inhibited reductions in gastric emptying and gastrointestinal motility induced by dopamine (1mg/kg, intraperitoneal injection, ip). Neither the powder, swertiamarin, nor itopride had any effect on the reductions in gastric emptying and gastrointestinal motility caused by 5-HT (4 mg/kg, ip). These findings suggest that the powder and swertiamarin stimulate gastric emptying and gastrointestinal motility by inhibiting the dopamine D(2) receptor.
獐牙菜在日本临床上被用作治疗胃肠道症状的药物。我们研究了獐牙菜和獐牙菜苦苷对阿托品、多巴胺和 5-羟色胺（5-HT）处理的小鼠胃排空和胃肠动力的影响。这三种制剂均能抑制多巴胺（1mg/kg，腹腔注射，ip）引起的胃排空和胃肠动力降低。粉末、獐牙菜苦苷和伊托必利对 5-HT（4mg/kg，ip）引起的胃排空和胃肠动力降低均无影响。这些发现表明，粉末和獐牙菜苦苷通过抑制多巴胺 D2 受体刺激胃排空和胃肠动力。
