IEEE Trans Biomed Eng. 2011 Aug;58(8). doi: 10.1109/TBME.2011.2153850. Epub 2011 May 12.
The transverse intrafascicular multichannel electrode (TIME) is intended to be transversally implanted in the peripheral nerve and to selectively interface subsets of axons in different fascicles within the same nerve. Two versions of TIME (TIME-2, TIME-3) were designed and tested for biocompatibility and safety in the sciatic nerve of the rat. TIME-2 was implanted in two groups: one group had only an acute implant and the second group had chronic implantation for 2 months; a third group was also chronically implanted with the TIME-3 version, designed to avoid the mechanical traction produced by muscles motion. We evaluated the functional and morphological effects of either TIME-2 or TIME-3 implanted in the rat sciatic nerve for 2 months. The results of the study indicate that implantation of the TIME-2 and TIME-3 devices in the rat sciatic nerve did not cause significant axonal loss or demyelination, as evidenced by the functional and histological results. The results of this study indicate that the TIME-2 and TIME-3 designs are biocompatible and safe after chronic implantation in a small peripheral nerve, such as the rat sciatic nerve.
横向纤维内多通道电极（TIME）旨在横向植入周围神经，并在同一神经内的不同纤维束中选择性地与轴突的亚群进行接口。设计了两种版本的 TIME（TIME-2、TIME-3），并在大鼠坐骨神经中测试其生物相容性和安全性。TIME-2 植入两组：一组只有急性植入，第二组慢性植入 2 个月；第三组也用设计用于避免肌肉运动产生的机械牵引的 TIME-3 版本进行慢性植入。我们评估了在大鼠坐骨神经中植入 TIME-2 或 TIME-3 长达 2 个月的功能和形态学影响。研究结果表明，在大鼠坐骨神经中植入 TIME-2 和 TIME-3 装置不会导致明显的轴突丢失或脱髓鞘，这从功能和组织学结果中可以得到证明。这项研究的结果表明，TIME-2 和 TIME-3 设计在小型周围神经（如大鼠坐骨神经）中进行慢性植入后具有生物相容性和安全性。
