Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42899, South Korea.
Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine, 05505, Seoul, South Korea.
Adv Sci (Weinh). 2023 Dec;10(35):e2303728. doi: 10.1002/advs.202303728. Epub 2023 Oct 15.
Intuitive and perceptual neuroprosthetic systems require a high degree of neural control and a variety of sensory feedback, but reliable neural interfaces for long-term use that maintain their functionality are limited. Here, a novel hybrid bionic interface is presented, fabricated by integrating a biological interface (regenerative peripheral nerve interface (RPNI)) and a peripheral neural interface to enhance the neural interface performance between a nerve and bionic limbs. This interface utilizes a shape memory polymer buckle that can be easily implanted on a severed nerve and make contact with both the nerve and the muscle graft after RPNI formation. It is demonstrated that this interface can simultaneously record different signal information via the RPNI and the nerve, as well as stimulate them separately, inducing different responses. Furthermore, it is shown that this interface can record naturally evoked signals from a walking rabbit and use them to control a robotic leg. The long-term functionality and biocompatibility of this interface in rabbits are evaluated for up to 29 weeks, confirming its promising potential for enhancing prosthetic control.
直观和感知神经假体系统需要高度的神经控制和各种感觉反馈，但可靠的长期使用的神经接口，以保持其功能是有限的。在这里，提出了一种新颖的混合仿生界面，通过集成生物接口（再生周围神经接口（RPNI））和周围神经接口来增强神经和仿生肢体之间的神经接口性能。该接口利用形状记忆聚合物扣，可轻松植入切断的神经上，并在 RPNI 形成后与神经和肌肉移植物接触。结果表明，该接口可以通过 RPNI 和神经同时记录不同的信号信息，也可以分别刺激它们，从而引起不同的反应。此外，还表明该接口可以记录行走兔子的自然诱发信号，并使用它们来控制机器腿。在兔子中评估了该接口长达 29 周的长期功能和生物相容性，证实了其增强假体控制的潜力。
