Molina V A, Volosin M, Cancela L, Keller E, Murúa V S, Basso A M
Departamento de Farmacología, Facultad de Ciencias Químicas Universidad Nacional de Córdoba, Argentina.
Pharmacol Biochem Behav. 1990 Feb;35(2):335-40. doi: 10.1016/0091-3057(90)90165-e.
Adult male rats were exposed to a series of unpredictable stressors, a paradigm considered to be a model of experimental depression, with or without concurrent administration of imipramine. One day after the last stress event of the chronic regime, binding of cortical beta-adrenoreceptors and the behavioral serotonin (5-HT) syndrome induced by 5-methoxy-N,N,dimethyltryptamine (5-MeODMT) were determined in all the experimental groups. Stressed rats showed an "up-regulation" of cortical beta-adrenergic sites, while similar values to control rats were observed when stressed animals were administered imipramine. Regarding the behavioral 5-HT syndrome, comparable behavioral scores were observed between controls and chronically stressed rats. The combination of chronic exposure to different stressors with imipramine treatment resulted in a significant increase of forepaw treading and Straub tail scores. The probable facilitation of behavioral deficits induced by this scheme of chronic stress and the recovery following concurrent administration of imipramine are discussed.
成年雄性大鼠暴露于一系列不可预测的应激源下，这是一种被认为是实验性抑郁模型的范式，同时给予或不给予丙咪嗪。在慢性应激方案的最后一次应激事件发生一天后，测定了所有实验组皮质β-肾上腺素能受体的结合情况以及5-甲氧基-N，N-二甲基色胺（5-MeODMT）诱导的行为性5-羟色胺（5-HT）综合征。应激大鼠表现出皮质β-肾上腺素能位点的“上调”，而当给应激动物服用丙咪嗪时，观察到的值与对照大鼠相似。关于行为性5-HT综合征，在对照组和慢性应激大鼠之间观察到了相当的行为评分。长期暴露于不同应激源与丙咪嗪治疗相结合导致前爪踩踏和施特劳布尾评分显著增加。本文讨论了这种慢性应激方案可能导致行为缺陷的易化作用以及同时给予丙咪嗪后的恢复情况。
