Murua V S, Gomez R A, Andrea M E, Molina V A
Escuela de Psicologia, Faculatad de Filosofia y Humanidades, Universidad Nacional de Cordoba, Argentina.
Pharmacol Biochem Behav. 1991 Jan;38(1):125-30. doi: 10.1016/0091-3057(91)90599-w.
Escape performance in a shuttle-box task was evaluated in rats chronically exposed to a series of unpredictable stressors either during 14 or 7 consecutive days. Failure in escape responses was observed when animals were subjected to both regimes of variable aversive situations. The association between chronic exposure to unpredictable stressors with imipramine resulted in a significant reversal of escape deficits. Furthermore, animals submitted to repeated immobilization sessions during 7 days presented similar escape response to control rats. A possible involvement of beta-adrenergic sites on this behavioral response is discussed.
在穿梭箱任务中，对连续14天或7天长期暴露于一系列不可预测应激源的大鼠的逃避表现进行了评估。当动物处于两种可变厌恶情境模式下时，均观察到逃避反应失败。长期暴露于不可预测应激源与丙咪嗪之间的关联导致逃避缺陷显著逆转。此外，在7天内接受重复固定疗程的动物表现出与对照大鼠相似的逃避反应。本文讨论了β-肾上腺素能位点可能参与这种行为反应的情况。
