Faculty of Medicine, University of Ottawa.
J Glaucoma. 2012 Feb;21(2):112-5. doi: 10.1097/IJG.0b013e318202791c.
To compare the effectiveness of argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT) in lowering intraocular pressure (IOP) in younger patients (age 60 or less).
This was a prospective randomized control trial. Forty-two young patients (age 29 to 60 y) had 1 eye randomized to ALT (n=22) or SLT (n=20). IOP was measured before laser and 1 hour, 1 day, 6 weeks, 3 months, every 3 months until 2 years, and then yearly postlaser. Chi-square analysis and Student t test were used to determine statistical significance.
The mean IOP before treatment was 21.9 mm Hg for ALT and 19.1 mm Hg for SLT with no statistical difference between the groups (P>0.05). At 2 years, 86.4% of ALT and 75.0% of SLT eyes required no further surgical intervention (laser trabeculoplasty or trabeculectomy). During the same time period, there was a statistically significant IOP decrease of 11.1% after ALT (P=0.01) and 7.7% after SLT (P=0.01) with no statistical difference between the lasers (P>0.05).
In younger patients, both ALT and SLT have a significant ocular hypotensive effect 2 years after treatment, with no differences in outcome identified between the laser modalities.
比较氩激光小梁成形术（ALT）和选择性激光小梁成形术（SLT）在降低 60 岁以下年轻患者眼内压（IOP）方面的效果。
这是一项前瞻性随机对照试验。42 名年龄在 29 至 60 岁的年轻患者（n=42），其中一只眼随机接受 ALT（n=22）或 SLT（n=20）治疗。在激光治疗前、治疗后 1 小时、1 天、6 周、3 个月、每 3 个月直至 2 年，以及之后每年测量 IOP。采用卡方分析和学生 t 检验来确定统计学意义。
ALT 组治疗前平均 IOP 为 21.9mmHg，SLT 组为 19.1mmHg，两组间无统计学差异（P>0.05）。2 年后，86.4%的 ALT 眼和 75.0%的 SLT 眼无需进一步手术干预（激光小梁成形术或小梁切除术）。在同一时期，ALT 组的 IOP 下降了 11.1%，SLT 组下降了 7.7%，具有统计学意义（P=0.01 和 P=0.01），两种激光之间无统计学差异（P>0.05）。
在年轻患者中，ALT 和 SLT 在治疗后 2 年均具有显著的降低眼压效果，两种激光之间的治疗效果无差异。
