干扰素-γ 诱导进行性黑质纹状体变性和基底节钙化。
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.
机构信息
Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
出版信息
Nat Neurosci. 2011 Jun;14(6):694-6. doi: 10.1038/nn.2829. Epub 2011 May 15.
Abstract
We found that CNS-directed expression of interferon-γ (IFN-γ) resulted in basal ganglia calcification, reminiscent of human idiopathic basal ganglia calcification (IBGC), and nigrostriatal degeneration. Our results indicate that IFN-γ mediates age-progressive nigrostriatal degeneration in the absence of exogenous stressors. Further study of this model may provide insight into selective nigrostriatal degeneration in human IBGC and other Parkinson syndromes.
摘要
我们发现，干扰素-γ（IFN-γ）在中枢神经系统中的表达导致基底节钙化，使人联想到特发性基底节钙化（IBGC）和黑质纹状体变性。我们的结果表明，IFN-γ在没有外源应激的情况下介导年龄进展性黑质纹状体变性。对该模型的进一步研究可能为人类 IBGC 和其他帕金森综合征中选择性黑质纹状体变性提供深入了解。
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