多巴胺转运体单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）及脑灌注单光子发射计算机断层扫描成像在特发性基底节钙化中的应用

Dopamine transporter SPECT/CT and perfusion brain SPECT imaging in idiopathic basal ganglia calcinosis.

作者信息

Paschali Anna, Lakiotis Velissarios, Messinis Lambros, Markaki Elli, Constantoyannis Constantine, Ellul John, Vassilakos Pavlos

机构信息

Department of Nuclear Medicine, Patras Medical School, General University Hospital of Patras, Patras, Greece.

出版信息

Clin Nucl Med. 2009 Jul;34(7):421-3. doi: 10.1097/RLU.0b013e3181a7d195.

DOI:10.1097/RLU.0b013e3181a7d195

PMID:19542944

Abstract

A case of idiopathic basal ganglia calcification in a 56-year-old woman with parkinsonism and cognitive impairment is described. The nigrostriatal dopaminergic pathway and regional cerebral blood flow were evaluated using dopamine transporter (DAT) brain single photon emission tomography combined with a low-dose x-ray computerized tomography transmission (hybrid SPECT/CT) and Tc-99m HMPAO brain perfusion SPECT study, respectively. DAT SPECT/CT imaging revealed a reduction in DAT binding in both striatum regions coinciding with bilateral calcifications in the basal ganglia. Brain perfusion scan showed hypoperfusion in basal ganglia regions, posterior parietal cortex bilaterally, left frontopolar and dorsolateral prefrontal cortex, and left temporal lobe. These findings correlated well with the clinical condition of the patient. Mineralization may play a critical role in the pathogenesis of neuronal degeneration. Cortical perfusion changes in patients may better explain the patient's altered cognitive and motor functions.

摘要

描述了一例56岁患有帕金森症和认知障碍的女性特发性基底节钙化病例。分别使用多巴胺转运体（DAT）脑单光子发射断层扫描结合低剂量x射线计算机断层扫描透射（混合SPECT/CT）和锝-99m六甲基丙二胺肟脑灌注SPECT研究评估黑质纹状体多巴胺能通路和局部脑血流量。DAT SPECT/CT成像显示两个纹状体区域的DAT结合减少，与基底节的双侧钙化一致。脑灌注扫描显示基底节区域、双侧顶叶后皮质、左额极和背外侧前额叶皮质以及左颞叶灌注不足。这些发现与患者的临床状况密切相关。矿化可能在神经元变性的发病机制中起关键作用。患者的皮质灌注变化可能更好地解释患者认知和运动功能的改变。