嘌呤能信号在排尿功能障碍中的作用。
Role of Purinergic Signaling in Voiding Dysfunction.
作者信息
Sun Yan, Chai Toby C
机构信息
Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
出版信息
Curr Bladder Dysfunct Rep. 2010 Aug 26;5(4):219-224. doi: 10.1007/s11884-010-0063-6.
Abstract
Purinergic signaling is a term that relates to adenosine triphosphate binding to its receptor (purinergic receptors such as P2X and P2Y subtypes). This pathway has been implicated in bladder functional disorders related to interstitial cystitis/painful bladder syndrome, neurogenic bladder secondary to spinal cord injury, lower urinary tract symptoms, diabetes, and aging. Purinergic signaling occurs at multiple sites, including the central nervous system, peripheral motor and sensory nerves, detrusor smooth muscle, and bladder urothelium. Future pharmacologic agents to treat bladder functional disorders may be able to target purinergic signaling at one or more of these sites.
摘要
嘌呤能信号传导是一个与三磷酸腺苷与其受体（如P2X和P2Y亚型等嘌呤能受体）结合相关的术语。该通路与间质性膀胱炎/膀胱疼痛综合征、脊髓损伤继发的神经源性膀胱、下尿路症状、糖尿病和衰老相关的膀胱功能障碍有关。嘌呤能信号传导发生在多个部位，包括中枢神经系统、外周运动和感觉神经、逼尿肌平滑肌和膀胱尿路上皮。未来用于治疗膀胱功能障碍的药物可能能够针对这些部位中的一个或多个来靶向嘌呤能信号传导。
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