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电针通过抑制膀胱P2X受体减轻膀胱过度活动症

Electroacupuncture Alleviates Bladder Overactivity via Inhabiting Bladder P2X Receptor.

作者信息

Feng Qi-Fan, Zhang An-Dong, Xing Man, Wang Xi, Ming Shu-Ren, Chen Yue-Lai

机构信息

Hainan Traditional Chinese Medicine Hospital, Haikou, Hainan 570203, China.

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Chinese Medicine, Shanghai 200437, China.

出版信息

Evid Based Complement Alternat Med. 2020 Mar 16;2020:4080891. doi: 10.1155/2020/4080891. eCollection 2020.

DOI:10.1155/2020/4080891
PMID:32256644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7103056/
Abstract

Electroacupuncture (EA) has been widely applied for overactive bladder, but the mechanism of its action remains to be clarified. This study was aimed to investigate EA regulating the effect of purinergic signaling in the OAB of rats. Electroacupuncture (continuous wave, 30 Hz, 1 mA) was applied to stimulate the Ciliao point (BL32) and the Huiyang point (BL35) of rats. Results showed that when the P2X receptor in bladder peripheral level and the spinal cord central level was involved in the bladder micturition reflex of the afferent signaling, intravenous administration P2X antagonist AF-353 can significantly inhibit urination in naive rats and OAB of rats and increase bladder volume and micturition pressure. EA stimulation alleviated bladder overactivity significantly and after the P2X receptor was blocked, the EA effect was weakened. EA stimulation can effectively reduce the P2X mRNA and protein expression in OAB of rats, spinal cord (L6-S1), and DRG (L6-S1) and can significantly reduce the number of positive P2X cells in OAB of rats, spinal cord (L6-S1), and DRG (L6-S1). These findings suggest that EA stimulation could alleviate bladder overactivity, and the function is closely related to the inhabited P2X receptor in the bladder.

摘要

电针已被广泛应用于治疗膀胱过度活动症，但其作用机制仍有待阐明。本研究旨在探讨电针对大鼠膀胱过度活动症中嘌呤能信号传导的调节作用。采用电针（连续波，30Hz，1mA）刺激大鼠的次髎穴（BL32）和会阳穴（BL35）。结果显示，当膀胱外周水平和脊髓中枢水平的P2X受体参与膀胱排尿反射的传入信号传导时，静脉注射P2X拮抗剂AF-353可显著抑制正常大鼠和大鼠膀胱过度活动症的排尿，并增加膀胱容量和排尿压力。电针刺激可显著减轻膀胱过度活动，P2X受体阻断后，电针效果减弱。电针刺激可有效降低大鼠膀胱过度活动症、脊髓（L6-S1）和背根神经节（L6-S1）中P2X mRNA和蛋白表达，并可显著减少大鼠膀胱过度活动症、脊髓（L6-S1）和背根神经节（L6-S1）中P2X阳性细胞数量。这些结果表明，电针刺激可减轻膀胱过度活动，其作用与膀胱中P2X受体的抑制密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb11/7103056/83ffaa2bfd95/ECAM2020-4080891.010.jpg
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