Efentaki Pinelopi, Altenburg Andreas, Haerting Johannes, Zouboulis Christos C
Departments of Dermatology, Venereology, Allergology and Immunology; Dessau Medical Center; Dessau, Germany.
Dermatoendocrinol. 2009 Nov;1(6):310-3. doi: 10.4161/derm.1.6.11236.
Although the exact etiology of alopecia areata is still unknown, systemic prednisolone treatment seem to be effective in early stages but significant side effects may occur leading to discontinuation of treatment.
Evaluation of efficacy and saftety of a short-term medium-dose pulse prednisolone treatment in alopecia areata.
84% of the patients with multifocal alopecia areata markedly improved after the completion of the three courses. A patient with the ophiasis type only responded after the third course, but relapsed 7 months later. The patients with alopecia areata totalis and universalis did not respond to the treatment. No major side effects were observed.
Monocenter prospective study of intravenous 100 mg intravenous prednisolone pulse therapy on 3 consecutive days at 1-month-intervals for three courses in 23 patients with active alopecia areata rapidly evolving and/or resistant to topical therapies and no contraindication for systemic steroids.
A series of three monthly courses of medium-dose prednisolone pulse therapy is effective and well tolerated in most patients with active, multifocal alopecia areata. The results are rather disappointing in patients with alopecia areara totalis/universalis.
尽管斑秃的确切病因仍不清楚，但全身用泼尼松龙治疗在早期似乎有效，但可能会出现严重副作用，导致治疗中断。
评估短期中等剂量脉冲式泼尼松龙治疗斑秃的疗效和安全性。
84% 的多灶性斑秃患者在完成三个疗程后明显改善。一名匐行性斑秃患者仅在第三个疗程后有反应，但7个月后复发。全秃和普秃患者对治疗无反应。未观察到重大副作用。
对23例活动性斑秃快速进展和/或对局部治疗耐药且无全身用类固醇禁忌证的患者进行单中心前瞻性研究，静脉注射100mg泼尼松龙脉冲疗法，连续3天，间隔1个月，共三个疗程。
一系列三个月疗程的中等剂量泼尼松龙脉冲疗法对大多数活动性、多灶性斑秃患者有效且耐受性良好。全秃/普秃患者的结果相当令人失望。
