Biswas Sreyasi, Manikandan Jayapal, Pushparaj Peter Natesan
Bioinformation. 2011 May 7;6(4):153-7. doi: 10.6026/97320630006153.
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unidentified aetiology, chiefly affecting the synovial membranes of joints, cartilage, bone, bursa and tendon sheath. Osteoarthritis (OA) is a degenerative disorder and encompass different sets of pathogenic pathways than RA; however, it shows a medley of clinical manifestations or symptoms resembling RA. Hence, we intend to identify more disease specific biomarkers through the meta-analysis of microarray datasets that can be crucial in the differential diagnosis, disease specific treatment as well as management of both RA and OA in a typical clinical setting.
类风湿性关节炎（RA）是一种病因不明的慢性全身性炎症性疾病，主要影响关节滑膜、软骨、骨骼、滑囊和腱鞘。骨关节炎（OA）是一种退行性疾病，其致病途径与RA不同；然而，它表现出一系列类似于RA的临床表现或症状。因此，我们打算通过对微阵列数据集进行荟萃分析来识别更多疾病特异性生物标志物，这些生物标志物在典型临床环境中对RA和OA的鉴别诊断、疾病特异性治疗以及管理至关重要。
