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玻璃体内注射曲安奈德在一名妊娠糖尿病性黄斑水肿患者中的超说明书用药。

Off-label use of intravitreal triamcinolone acetonide for diabetic macular edema in a pregnant patient.

作者信息

Fazelat Ahad, Lashkari Kameran

机构信息

Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA.

出版信息

Clin Ophthalmol. 2011;5:439-41. doi: 10.2147/OPTH.S14584. Epub 2011 Apr 7.

DOI:10.2147/OPTH.S14584
PMID:21573089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3090296/
Abstract

We present a case of diabetic macular edema in a pregnant patient treated with a single intravitreal injection of triamcinolone acetonomide. Initial presentation and serial examinations after treatment included visual acuity, slit-lamp examination, indirect ophthalmoscopy, and optical coherence tomography. Resolution of visual acuity and macular edema were present six weeks after injection and persisted throughout the duration of the pregnancy without further intervention. No adverse outcomes for either mother or fetus were noted. To our knowledge, this is the first report of intravitreal triamcinolone administration in this patient population to be published in the medical literature.

摘要

我们报告了一例接受单次玻璃体内注射曲安奈德治疗的妊娠糖尿病性黄斑水肿患者。治疗后的初始表现和系列检查包括视力、裂隙灯检查、间接检眼镜检查和光学相干断层扫描。注射后六周视力和黄斑水肿消退,且在整个孕期持续存在,无需进一步干预。未观察到对母亲或胎儿的不良后果。据我们所知,这是该患者群体中玻璃体内注射曲安奈德的首次报道,已发表于医学文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b0/3090296/6450e47328e4/opth-5-439f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b0/3090296/37ac2612eeb1/opth-5-439f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b0/3090296/a30b217ac321/opth-5-439f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b0/3090296/6450e47328e4/opth-5-439f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b0/3090296/37ac2612eeb1/opth-5-439f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b0/3090296/a30b217ac321/opth-5-439f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2b0/3090296/6450e47328e4/opth-5-439f3.jpg

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本文引用的文献

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A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema.一项比较玻璃体内注射曲安奈德与局部/格栅光凝治疗糖尿病性黄斑水肿的随机试验。
Ophthalmology. 2008 Sep;115(9):1447-9, 1449.e1-10. doi: 10.1016/j.ophtha.2008.06.015. Epub 2008 Jul 26.
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Intravitreal triamcinolone acetonide for diabetic macular edema.玻璃体内注射曲安奈德治疗糖尿病性黄斑水肿。
Retina. 2005 Oct-Nov;25(7):828-34. doi: 10.1097/00006982-200510000-00002.
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Histopathological findings of cleft palate in rat embryos induced by triamcinolone acetonide.
Indian J Ophthalmol. 2021 Nov;69(11):3015-3025. doi: 10.4103/ijo.IJO_1377_21.
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Role of Oral Antioxidant Supplementation in the Current Management of Diabetic Retinopathy.口服抗氧化剂补充剂在糖尿病视网膜病变治疗中的作用。
Int J Mol Sci. 2021 Apr 13;22(8):4020. doi: 10.3390/ijms22084020.
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Diabetic retinopathy and diabetic macular oedema pathways and management: UK Consensus Working Group.糖尿病视网膜病变和糖尿病黄斑水肿的诊治途径:英国共识工作组。
Eye (Lond). 2020 Jun;34(Suppl 1):1-51. doi: 10.1038/s41433-020-0961-6.
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Dexamethasone intravitreal implant for diabetic macular edema in a pregnant patient.地塞米松玻璃体内植入物用于治疗一名孕妇的糖尿病性黄斑水肿
Int J Ophthalmol. 2016 Oct 18;9(10):1524-1527. doi: 10.18240/ijo.2016.10.26. eCollection 2016.
曲安奈德诱导的大鼠胚胎腭裂的组织病理学发现。
J Vet Med Sci. 2004 Apr;66(4):397-402. doi: 10.1292/jvms.66.397.
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