FISABIO-Oftalmología Médica (FOM), Vitreoretinal Unit, 46015 Valencia, Spain.
Servicio de Oftalmología, Hospital General Universitario de Castellón, 12004 Castellón, Spain.
Int J Mol Sci. 2021 Apr 13;22(8):4020. doi: 10.3390/ijms22084020.
Oxidative stress has been postulated as an underlying pathophysiologic mechanism of diabetic retinopathy (DR), the main cause of avoidable blindness in working-aged people. This review addressed the current daily clinical practice of DR and the role of antioxidants in this practice. A systematic review of the studies on antioxidant supplementation in DR patients was presented. Fifteen studies accomplished the inclusion criteria. The analysis of these studies concluded that antioxidant supplementation has a IIB level of recommendation in adult Type 1 and Type 2 diabetes mellitus subjects without retinopathy or mild-to-moderate nonproliferative DR without diabetic macular oedema as a complementary therapy together with standard medical care.
氧化应激被认为是糖尿病视网膜病变（DR）的潜在病理生理机制，DR 是导致工作年龄段人群可避免失明的主要原因。本综述探讨了 DR 的当前临床实践以及抗氧化剂在该实践中的作用。本文呈现了抗氧化剂补充剂在 DR 患者中应用的系统综述。有 15 项研究符合纳入标准。对这些研究的分析得出结论，在没有糖尿病黄斑水肿的 1 型和 2 型糖尿病成年患者中，抗氧化剂补充剂作为标准医疗护理的补充疗法，对没有视网膜病变或轻度至中度非增生性 DR 具有 IIB 级别的推荐。
