Bernard D, Gosse S, Bignon Y
COMPLEXE UNIV CEZEAUX,IMMUNOL GIGNOSQUE LAB,F-63170 CLERMONT FERRAND,FRANCE.
Int J Oncol. 1993 May;2(5):827-30. doi: 10.3892/ijo.2.5.827.
Knowledge of the genetics of colon cancer has already started to have an impact on prevention, early detection and control strategies for large bowel malignancy. This report reviews the genetics of colorectal cancer, both the epidemiological and molecular aspects. It includes a description of the syndromes of inherited colorectal cancer and a discussion of recent molecular genetic work about tumor suppressor genes.
结肠癌遗传学知识已开始对大肠癌的预防、早期检测及控制策略产生影响。本报告回顾了结直肠癌的遗传学，包括流行病学和分子方面。它描述了遗传性结直肠癌综合征，并讨论了近期关于肿瘤抑制基因的分子遗传学研究工作。
