双硫仑的代谢产物二乙二硫代氨基甲酸盐在犬体内的处置动力学。 - Suppr

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超能文献

Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram.

作者信息

Cobby J, Mayersohn M, Selliah S

出版信息

J Pharmacokinet Biopharm. 1978 Oct;6(5):369-87. doi: 10.1007/BF01062720.

DOI:10.1007/BF01062720

PMID:215740

Abstract

摘要

相似文献

Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram.双硫仑的代谢产物二乙二硫代氨基甲酸盐在犬体内的处置动力学。

J Pharmacokinet Biopharm. 1978 Oct;6(5):369-87. doi: 10.1007/BF01062720.

Bis-(diethyldithiocarbamato) copper complex: a new metabolite of disulfiram?双（二乙基二硫代氨基甲酸盐）铜配合物：双硫仑的一种新代谢物？

Biochem Pharmacol. 1985 Aug 15;34(16):2989-91. doi: 10.1016/0006-2952(85)90026-7.

Absorption, elimination and duration of action of diethyldithiocarbamate in animals [proceedings].二乙基二硫代氨基甲酸盐在动物体内的吸收、消除及作用持续时间[会议论文集]

J Pharm Pharmacol. 1976 Dec;28 Suppl:38P.

Technetium-99m-labelled N,N-diethyldithiocarbamate--a non-polar complex with slow hepatic clearance.锝-99m标记的N,N-二乙基二硫代氨基甲酸盐——一种具有缓慢肝脏清除率的非极性复合物。

Int J Nucl Med Biol. 1981;8(1):112-4. doi: 10.1016/0047-0740(81)90062-0.

In vitro formation of methyldiethyldithiocarbamate after the reaction of nitrosoacetoxymethylmethylamine or methylnitrosourea with disulfiram.亚硝基乙酰氧基甲基甲胺或甲基亚硝基脲与双硫仑反应后在体外形成甲基二乙基二硫代氨基甲酸盐。

Carcinogenesis. 1982;3(11):1361-6. doi: 10.1093/carcin/3.11.1361.

Impairment of hepatic microsomal and plasma esterases of the rat by disulfiram and diethyldithiocarbamate.双硫仑和二乙基二硫代氨基甲酸盐对大鼠肝脏微粒体酯酶和血浆酯酶的损害。

Biochem Pharmacol. 1976 Feb 15;25(4):453-9. doi: 10.1016/0006-2952(76)90349-x.

Effect of thiuram sulphides on the uptake and distribution of nickel in pregnant and non-pregnant mice.秋兰姆硫化物对怀孕和未怀孕小鼠体内镍摄取与分布的影响。

Toxicology. 1984 Sep 28;32(4):297-313. doi: 10.1016/0300-483x(84)90082-9.

Effect of disulfiram (tetraethylthiuram disulfide) amd diethyldithiocarbamate on the bladder toxicity and antitumor activity of cyclophosphamide in mice.双硫仑（二硫化四乙秋兰姆）和二乙基二硫代氨基甲酸盐对小鼠环磷酰胺膀胱毒性及抗肿瘤活性的影响。

Cancer Res. 1982 Nov;42(11):4490-4.

Use of diethyldithiocarbamate as a probe to detect stable intermediates during the decomposition of several mutagenic and nonmutagenic N-nitroso compounds.使用二乙基二硫代氨基甲酸盐作为探针来检测几种诱变和非诱变N-亚硝基化合物分解过程中的稳定中间体。

J Cancer Res Clin Oncol. 1986;111(2):115-22. doi: 10.1007/BF00400748.

Methyl diethyldithiocarbamate, a metabolite of disulfiram in man.甲基二乙基二硫代氨基甲酸盐，人体内双硫仑的一种代谢产物。

Life Sci. 1977 Oct 1;21(7):937-42. doi: 10.1016/0024-3205(77)90259-4.

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Sudden Unexpected Death and Alcohol Addiction: Case Report on Disulfiram Use.猝死与酒精成瘾：关于使用双硫仑的病例报告

Acta Med Litu. 2025;32(1):153-159. doi: 10.15388/Amed.2025.32.1.5. Epub 2025 Feb 18.

Metabolite pharmacokinetics: the area under the curve of metabolite and the fractional rate of metabolism of a drug after different routes of administration for renally and hepatically cleared drugs and metabolites.代谢物药代动力学：肾清除和肝清除药物及代谢物经不同给药途径给药后代谢物的曲线下面积和药物代谢分数率。

J Pharmacokinet Biopharm. 1981 Aug;9(4):477-87. doi: 10.1007/BF01060890.

A review of metabolite kinetics.代谢物动力学综述。

J Pharmacokinet Biopharm. 1985 Dec;13(6):633-62. doi: 10.1007/BF01058905.

本文引用的文献

Treatment of alcoholism with a sensitizing drug.用一种致敏药物治疗酒精中毒。

Lancet. 1948 Dec 25;2(6539):1004. doi: 10.1016/s0140-6736(48)91515-3.

A method for the determination of tetraethylthiuram disulphide (Antabus, Abstinyl) and diethyldithiocarbamate in blood and urine; some studies on the metabolism of tetraethylthiuram disulphide.一种测定血液和尿液中四乙基秋兰姆二硫化物（戒酒硫、阿扑斯汀）和二乙基二硫代氨基甲酸盐的方法；关于四乙基秋兰姆二硫化物代谢的一些研究。

Scand J Clin Lab Invest. 1951;3(2):96-102. doi: 10.3109/00365515109060580.

The metabolism of tetraethyl thiuramdisulphide (antabus, aversan) in man, investigated by means of radioactive sulphar.用放射性硫研究了四乙秋兰姆二硫化物（戒酒硫，双硫醒）在人体中的代谢。

Scand J Clin Lab Invest. 1950;2(3):202-8. doi: 10.3109/00365515009049871.

The metabolism of the tetraethyl thiuramdisulphide (antabus, aversan) in the rat, investigated by means of radioactive sulphar.通过放射性硫对大鼠体内二硫化四乙秋兰姆（戒酒硫，戒酒硫）的代谢进行了研究。

Scand J Clin Lab Invest. 1950;2(3):198-201. doi: 10.3109/00365515009049870.

The stability of sodium diethyldithiocarbamate in biochemical experiments.二乙氨基二硫代甲酸钠在生化实验中的稳定性

Biochim Biophys Acta. 1959 Dec;36:538-40. doi: 10.1016/0006-3002(59)90199-4.

METABOLISM OF DISULFIRAM AND DIETHYLDITHIOCARBAMATE IN RATS WITH DEMONSTRATION OF AN IN VIVO ETHANOL-INDUCED INHIBITION OF THE GLUCURONIC ACID CONJUGATION OF THE THIOL.双硫仑和二乙基二硫代氨基甲酸盐在大鼠体内的代谢，并证明乙醇在体内对硫醇葡萄糖醛酸结合的抑制作用。

Biochem Pharmacol. 1965 Apr;14:393-410. doi: 10.1016/0006-2952(65)90213-3.

INTERACTIONS OF DISULFIRAM AND DIETHYLDITHIOCARBAMATE WITH SERUM PROTEINS STUDIED BY MEANS OF GEL-FILTRATION TECHNIQUE.用凝胶过滤技术研究双硫仑和二乙基二硫代氨基甲酸盐与血清蛋白的相互作用

Biochem Pharmacol. 1965 Apr;14:381-91. doi: 10.1016/0006-2952(65)90212-1.

Inhibition of hexokinase by disulfiram and diethyldithiocarbamate.双硫仑和二乙基二硫代氨基甲酸盐对己糖激酶的抑制作用。

Biochem Pharmacol. 1963 Feb;12:157-66. doi: 10.1016/0006-2952(63)90180-1.

Formation of an S-glucuronide from tetraethylthiuram disulfide (Antabuse) in man.人体中由二硫化四乙秋兰姆（戒酒硫）形成S-葡糖醛酸苷。

Biochim Biophys Acta. 1963 Jun 4;71:730-1. doi: 10.1016/0006-3002(63)91149-1.

[Content of carbon disulfide in the air expired by normal persons and by persons under the influence of ethyl alcohol during treatment by Antabuse (disulfiram) and sodium diethyldithiocarbamate].[正常人以及在使用安塔布司（双硫仑）和二乙氨基二硫代甲酸钠治疗期间受乙醇影响的人呼出空气中的二硫化碳含量]

Arch Int Pharmacodyn Ther. 1961 Jul 1;132:427-53.

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