Kondratavičiūtė Gabija, Banionis Dalius, Laima Sigitas, Chmieliauskas Sigitas, Vasiljevaitė Diana, Petreikis Paulius, Badaras Robertas
Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Department of Pathology, Forensic Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Acta Med Litu. 2025;32(1):153-159. doi: 10.15388/Amed.2025.32.1.5. Epub 2025 Feb 18.
Disulfiram is a type of medication widely prescribed in order to cease alcohol consumption. When used with alcohol, the 'disulfiram-alcohol reaction' occurs, causing nausea and vomiting. Disulfiram blocks alcohol dissolving enzymes thus increasing acetaldehyde concentration and inducing the above-mentioned symptoms. These undesirable symptoms are similar to the side effects that occur to oncological patients after the administration of chemotherapy.
Descriptive research method was used. The literature focusing on alcohol, medications and drug consumption was reviewed.
The primary abstinence at the beginning of treatment with does not guarantee that alcohol usage will not get manifested again at the further stages of treatment. Alcohol addiction forces patients to search for a way to avoid the unwanted reactions. Sometimes, patients tend to be quite ingenious while trying to suppress the arising side effects. In many cases, it involves the usage of additional medication.
When alcohol addiction overpowers, the patient tries to reduce the undesirable symptoms and may even die if alcohol is combined with disulfiram. Death may occur due to the cardio and neurotoxic effects of acetaldehyde.
双硫仑是一种广泛用于戒酒的药物。与酒精一起使用时，会发生“双硫仑-酒精反应”，导致恶心和呕吐。双硫仑会阻断酒精溶解酶，从而增加乙醛浓度并引发上述症状。这些不良症状类似于肿瘤患者化疗后出现的副作用。
采用描述性研究方法。查阅了关于酒精、药物和药物消费的文献。
治疗开始时的初次戒酒并不能保证在治疗的后续阶段酒精使用不会再次出现。酒精成瘾迫使患者寻找避免不良反应的方法。有时，患者在试图抑制出现的副作用时会相当机智。在许多情况下，这涉及使用额外的药物。
当酒精成瘾占上风时，患者会试图减轻不良症状，如果酒精与双硫仑合用，甚至可能死亡。死亡可能是由于乙醛的心脏和神经毒性作用。
