Uniwersytet Jagielloński, Collegium Medicum, Katedra i Klinika Neurologii, ul. Botaniczna 3, 31-503 Kraków.
Neurol Neurochir Pol. 2011 Mar-Apr;45(2):148-52. doi: 10.1016/s0028-3843(14)60026-8.
A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke.
We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction.
Both univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive mo-dels. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors.
The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.
染色体 4q25 上的少数单核苷酸多态性（SNP）与心房颤动（AF）相关，是缺血性中风的危险因素。我们研究了染色体 4q25 上 SNP rs2200733 在不同类型心源性栓塞（CE）性中风中的意义。
我们对 428 名对照者和 301 名 CE 性中风患者进行了基因分型，其中 197 名（65.4%）存在高风险栓塞源（与 AF 相关的 CE 性中风），104 名存在中风险栓塞源（与 AF 无关的 CE 性中风）。使用实时多态性链式反应分析 SNP rs2200733。
单变量和多变量回归分析均表明，所研究的变异在隐性和加性模型中影响所有 CE 性中风或与 AF 相关的 CE 性中风的风险。两种类型的 CE 性中风在人口统计学和血管危险因素分布方面存在显著差异。
染色体 4q25 上的 SNP rs2200733 仅是与 AF 相关的 CE 性中风的危险因素。
