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[植物源转基因生物对大鼠三代后代发育影响的评估]

[Assessment of the impact of GMO of plant origin on rat progeny development in 3 generations].

作者信息

Tyshko N V, Zhminchenko V M, Pashorina V A, Seliaskin K E, Saprykin V P, Utembaeva N T, Tutel'ian V A

出版信息

Vopr Pitan. 2011;80(1):14-28.

PMID:21574464
Abstract

The publication presents the results of assessment of impact of genetically modified (GM) maize Liberty Link on prenatal and postnatal development of progeny of 3 generations of Wistar rats. A total of 630 adult animals and 2837 pups were used in the experiment. The animals were divided into 5 groups which got the diets with inclusion of maize: the animals of the experimental group got the diet with the GM-maize, animals of the control group - with near isogenic conventional analogue of the GM-maize, animals of the 1st, 2nd and 3rd reference groups - conventional varieties of maize ROSS 144 MV, ROSS 197 MVW, Dokuchayevskaya 250 MV respectively. The maize was included in the diet at maximum possible level not violating the balance of basic nutrients. Analysis of the data obtained during the study did not reveal any impact of GM-maize on rat progeny development.

摘要

该出版物展示了转基因(GM)玉米利比里特对三代Wistar大鼠后代产前和产后发育影响的评估结果。实验共使用了630只成年动物和2837只幼崽。动物被分为5组,给予含玉米的饮食:实验组动物给予含转基因玉米的饮食,对照组动物给予转基因玉米的近等基因常规类似物,第一、第二和第三参考组动物分别给予常规玉米品种ROSS 144 MV、ROSS 197 MVW、Dokuchayevskaya 250 MV。玉米以不违反基本营养素平衡的最大可能水平纳入饮食。对研究期间获得的数据进行分析后,未发现转基因玉米对大鼠后代发育有任何影响。

相似文献

1
[Assessment of the impact of GMO of plant origin on rat progeny development in 3 generations].[植物源转基因生物对大鼠三代后代发育影响的评估]
Vopr Pitan. 2011;80(1):14-28.
2
[Effect of genetically modified plants on the development of rat progeny].[转基因植物对大鼠后代发育的影响]
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Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13.
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Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-Ø15Ø7-1xDAS-59122-7) maize grain in Sprague-Dawley rats.用转基因叠加性状抗鳞翅目和鞘翅目(DAS-Ø15Ø7-1xDAS-59122-7)玉米谷物对斯普拉格-道利大鼠进行亚慢性喂养研究。
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Assessment of the impact of genetically modified LibertyLink maize on reproductive function and progeny development of Wistar rats in three generations.三代Wistar大鼠中转基因抗除草剂玉米对生殖功能和子代发育影响的评估
Toxicol Rep. 2014 Jun 11;1:330-340. doi: 10.1016/j.toxrep.2014.05.013. eCollection 2014.
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