α和β肾上腺素能拮抗剂可阻断禁食24小时大鼠的肾上腺素性厌食。

Adrenaline anorexia blocked by alpha and beta adrenergic antagonists in 24-h fasted rats.

作者信息

De-la-Cruz F, Soto-Mora M L, Uriostegui T, Russek M

机构信息

Department of Physiology, National School of Biological Sciences, IPN, Mexico, D.F.

出版信息

Behav Brain Res. 1990 Mar 5;37(2):145-8. doi: 10.1016/0166-4328(90)90089-w.

DOI:10.1016/0166-4328(90)90089-w

PMID:2157461

Abstract

The effect of alpha and beta adrenergic blockers, phentolamine (PH) and propranolol (PR), on the anorexia induced by intraperitoneal (i.p.) adrenaline (A) was studied in 24 h-fasting male and female adult Wistar rats. I.p. PH elicited a small but significant increase in food intake in both males and females. The combination of PH + PR completely blocked the anorexia elicited by i.p. A in both males and females. In females, PH and PR alone partially blocked A-induced anorexia. In males, PH had no significant effect on A-induced anorexia but PR blocked it completely. It was concluded that the relative participation of alpha and beta adrenergic receptors in A-induced anorexia seems to depend on the sex of the rat, at least for the doses used in the present study: in females, alpha and beta actions seem to be approximately equal, while in males the beta is predominant.

摘要

在禁食24小时的成年雄性和雌性Wistar大鼠中，研究了α和β肾上腺素能阻滞剂酚妥拉明（PH）和普萘洛尔（PR）对腹腔注射（i.p.）肾上腺素（A）诱导的厌食症的影响。腹腔注射PH在雄性和雌性大鼠中均引起食物摄入量的小幅但显著增加。PH + PR的组合完全阻断了雄性和雌性大鼠腹腔注射A引起的厌食症。在雌性大鼠中，单独使用PH和PR可部分阻断A诱导的厌食症。在雄性大鼠中，PH对A诱导的厌食症无显著影响，但PR可完全阻断。得出的结论是，α和β肾上腺素能受体在A诱导的厌食症中的相对参与程度似乎取决于大鼠的性别，至少对于本研究中使用的剂量而言：在雌性大鼠中，α和β作用似乎大致相等，而在雄性大鼠中β作用占主导。