Departamento de Psicoloxía Clínica e Psicobioloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Alcohol Clin Exp Res. 2011 Aug;35(8):1475-84. doi: 10.1111/j.1530-0277.2011.01484.x. Epub 2011 May 16.
Binge drinking (BD), which is characterized by sporadic consumption of large quantities of alcohol in short periods, is prevalent among university students. Animal studies have shown that BD is associated with damage to the hippocampus, a region of the brain that plays a key role in learning and memory. The temporal cortex undergoes structural and functional changes during adolescence. The aim of the present study was to examine the association between BD and declarative memory in male and female university students.
The participants were 122 students (between 18 and 20 years of age): 62 BD (30 women) and 60 non-BD (29 women). The neuropsychological assessment included the Rey Auditory Verbal Learning Test (RAVLT) and Weschler Memory Scale-3rd ed. (WMS-III) Logical Memory subtest, to evaluate verbal declarative memory, and the WMS-III Family Pictures subtest, to measure visual declarative memory.
The BD students remembered fewer words in the interference list and displayed greater proactive interference in the RAVLT; they performed worse in the Logical Memory subtest, both on immediate and delayed recall. There were no differences between the groups in performance of the Family Pictures subtest. No significant interactions were observed between BD and sex.
Binge drinking is associated with poorer verbal declarative memory, regardless of sex. The findings are consistent with the vulnerability of the adolescent hippocampus to the neurotoxic effects of alcohol. Longitudinal studies will help determine the nature of this relationship, the neurodevelopmental trajectories for each sex, and the repercussions on academic performance.
binge drinking（BD），即偶尔在短时间内大量饮酒，在大学生中很常见。动物研究表明，BD 与海马体损伤有关，海马体是大脑中在学习和记忆中起关键作用的区域。青春期期间，颞叶皮质会发生结构和功能变化。本研究旨在探讨 BD 与男性和女性大学生陈述性记忆之间的关系。
参与者为 122 名学生（年龄在 18 至 20 岁之间）：62 名 BD（30 名女性）和 60 名非 BD（29 名女性）。神经心理学评估包括 Rey 听觉言语学习测验（RAVLT）和韦氏记忆量表第 3 版（WMS-III）逻辑记忆子测验，以评估言语陈述性记忆，以及 WMS-III 家庭图片子测验，以测量视觉陈述性记忆。
BD 组学生在干扰列表中记住的单词较少，在 RAVLT 中表现出更大的前摄干扰；他们在逻辑记忆子测验中表现更差，无论是即时回忆还是延迟回忆。两组在家庭图片子测验中的表现没有差异。BD 与性别之间没有观察到显著的交互作用。
无论性别如何，BD 与较差的言语陈述性记忆有关。这些发现与青少年海马体对酒精神经毒性作用的易感性一致。纵向研究将有助于确定这种关系的性质、每个性别的神经发育轨迹，以及对学业成绩的影响。
