Departamento de Fundamentos de Psicologia, Instituto de Psicologia, Universidade do Estado do Rio de Janeiro, Rua São Francisco de Xavier, 524, 10̊ andar, Bloco B, Maracanã, Rio de Janeiro, Rio de Janeiro 20550-013, Brazil.
Drug Alcohol Depend. 2013 Nov 1;133(1):108-14. doi: 10.1016/j.drugalcdep.2013.05.024. Epub 2013 Jun 19.
Adolescence is a time of considerable neurodevelopment. Binge drinking (BD) during this period increases the vulnerability to its neurotoxic effects. This longitudinal study aimed to investigate the relationship between BD trajectory over university years and neuropsychological functioning.
Cohort-study. Two-year follow-up. A total of 89 university students were assessed: 40 Non-BD (at Initial and Follow-up), 16 Ex-BD (BD at Initial but not at Follow-up) and 33 BD (at both times). Neuropsychological assessment of working memory, episodic memory and executive abilities was carried out during their first (Initial) and third (Follow-up) academic year at the University of Santiago de Compostela.
BD subjects performed less well on the Wechsler Memory Scale-III (WMS-III) Logical Memory Subtest (immediate theme recall, P=.034; delayed theme recall, P=.037; and percent retention, P=.035) and committed more perseverative errors on the Self-Ordered Pointing Task (SOPT) (P=.021) than Non-BD. There were no differences between Ex-BD and Non-BD.
Binge drinking trajectory during adolescence is associated with neuropsychological performance. Persistent BD, but not Ex-BD, is associated with verbal memory and monitoring difficulties. This is compatible with the hypothesis that heavy alcohol use during adolescence may affect cognitive functions that rely on the temporomesial and dorsolateral prefrontal cortex.
青春期是大脑神经发育的重要时期。在此期间狂饮会增加其神经毒性作用的易感性。本纵向研究旨在探讨大学期间狂饮轨迹与神经心理功能之间的关系。
队列研究。为期两年的随访。共评估了 89 名大学生：40 名非狂饮者（在初始和随访时），16 名曾经狂饮者（在初始时狂饮，但在随访时不狂饮）和 33 名狂饮者（在两次评估时都狂饮）。在圣地亚哥德孔波斯特拉大学的第一年（初始）和第三年（随访），对他们进行了工作记忆、情景记忆和执行能力的神经心理学评估。
狂饮组在韦氏记忆量表-III（WMS-III）逻辑记忆子测验中的表现较差（即时主题回忆，P=.034；延迟主题回忆，P=.037；和保留率，P=.035），在自我有序指向任务（SOPT）中犯更多的持续错误（P=.021），而非狂饮组无差异。曾经狂饮者与非狂饮者之间也无差异。
青春期期间的狂饮轨迹与神经心理表现有关。持续的狂饮，但非曾经狂饮，与言语记忆和监控困难有关。这与以下假设一致，即青少年期大量饮酒可能会影响依赖于颞叶和背外侧前额叶皮质的认知功能。
