Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Division of Biostatistics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, USA.
Cereb Cortex. 2022 Jun 7;32(12):2611-2620. doi: 10.1093/cercor/bhab368.
The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was examined using 5 waves of longitudinal data from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study. Binge drinkers (n = 166) were compared with non-binge drinkers (n = 82 after matching on potential confounders). Number of binge drinking episodes in the past year was linked to decreased GMVs in bilateral Desikan-Killiany cortical parcellations (26 of 34 with P < 0.05/34) with the strongest effects observed in frontal regions. Interactions of binge drinking episodes and baseline age demonstrated stronger effects in younger participants. Statistical models sensitive to number of binge episodes and their temporal proximity to brain volumes provided the best fits. Consistent with prior research, results of this study highlight the negative effects of binge drinking on the developing brain. Our results present novel findings that cortical GMV decreases were greater in closer proximity to binge drinking episodes in a dose-response manner. This relation suggests a causal effect and raises the possibility that normal growth trajectories may be reinstated with alcohol abstinence.
尽管青少年 binge 饮酒是一个健康危机，但 binge 饮酒对青少年大脑发育的年龄和时间依赖性影响仍未得到充分描述。本研究使用青少年酒精与神经发育全国合作研究的 5 波纵向数据，考察了 binge 饮酒对灰质体积（GMV）发育的影响。将 binge 饮酒者（n = 166）与非 binge 饮酒者（匹配潜在混杂因素后 n = 82）进行比较。过去一年 binge 饮酒的次数与双侧 Desikan-Killiany 皮质分块（34 个中的 26 个，P < 0.05/34）的 GMV 减少有关，前额区域的影响最强。 binge 饮酒次数与基线年龄的相互作用在年龄较小的参与者中表现出更强的影响。对 binge 饮酒次数和其与脑容量时间接近程度敏感的统计模型提供了最佳拟合。与先前的研究一致，本研究的结果强调了 binge 饮酒对发育中大脑的负面影响。我们的结果提供了新的发现，即 binge 饮酒事件越接近，皮质 GMV 减少越多，呈剂量反应关系。这种关系提示存在因果效应，并有可能通过戒酒来恢复正常的生长轨迹。
