Li G, Zeng M
Zhonghua Yi Xue Za Zhi. 1990 Jan;70(1):16-9, 2.
Serum GH, E2, FSH, LH levels, bone mass, serum alkaline phosphatase (AKP), calcium levels and urinary calcium/creatine ratio in 42 postmenopausal women were compared with those in 30 women of fertile age. In thirteen out of the postmenopausal women we also observed these parameters before and after treatment with diethylstilbestrol (DES). The postmenopausal women had significantly reduced serum GH (P less than 0.01) and E2 levels (P less than 0.001) and increased serum FSH(P less than 0.001), LH levels (P less than 0.001), and had lower bone mass (P less than 0.01). They also had increased serum AKP levels (P less than 0.05) and urinary calcium/creatine ratio(P less than 0.01). There were positive correlations between serum E2 and GH levels, between postmenopausal bone loss and serum E2, GH decline. The postmenopausal bone loss began early as menopause commenced. After treatment with DES in 13 postmenopausal women, we observed that GH significantly increased (P less than 0.01) and FSH, LH decreased (P less than 0.001), AKP decreased by 27.58% and urinary calcium/creatine ratio decreased by 43.94% (compared with that before treatment). Our results indicate that bone turnover increased after menopause and resorption exceeded formation. There is bone loss in early postmenopause. The postmenopausal bone loss is related to serum GH, E2 levels. Estrogen replacement therapy is necessary in postmenopausal women and it should be given as early as possible. After treatment with DES, increased serum GH levels, decreased AKP values (27.58%) and urinary calcium/creatine ratio (43.94%) suggest that estrogen may play a definite role in bone metabolism through increased GH.
对42名绝经后女性的血清生长激素（GH）、雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素（LH）水平、骨量、血清碱性磷酸酶（AKP）、钙水平及尿钙/肌酐比值与30名育龄期女性进行了比较。在13名绝经后女性中，我们还观察了己烯雌酚（DES）治疗前后的这些参数。绝经后女性的血清GH水平显著降低（P<0.01），E2水平显著降低（P<0.001），血清FSH水平升高（P<0.001）、LH水平升高（P<0.001），且骨量较低（P<0.01）。她们的血清AKP水平也升高（P<0.05），尿钙/肌酐比值升高（P<0.01）。血清E2与GH水平之间、绝经后骨质流失与血清E2、GH下降之间存在正相关。绝经后骨质流失在绝经开始时就早早出现。13名绝经后女性经DES治疗后，我们观察到GH显著升高（P<0.01），FSH、LH降低（P<0.001），AKP下降27.58%，尿钙/肌酐比值下降43.94%（与治疗前相比）。我们的结果表明，绝经后骨转换增加，吸收超过形成。绝经后早期存在骨质流失。绝经后骨质流失与血清GH、E2水平有关。绝经后女性有必要进行雌激素替代治疗，且应尽早给予。DES治疗后，血清GH水平升高、AKP值下降（27.58%）和尿钙/肌酐比值下降（43.94%）表明，雌激素可能通过增加GH在骨代谢中发挥一定作用。
