利用荧光 pH 传感器选择性标记和监测活细胞溶酶体的 pH 变化。
Selective labeling and monitoring pH changes of lysosomes in living cells with fluorogenic pH sensors.
机构信息
Life Technologies, 29851 Willow Creek Road, Eugene, OR 97402, USA.
出版信息
Bioorg Med Chem Lett. 2011 Jun 15;21(12):3546-9. doi: 10.1016/j.bmcl.2011.04.137. Epub 2011 May 5.
PMID:21576021
Abstract
New BODIPY-based pH probes have been designed with excitation and emission wavelengths suitable for fluorescence microscopy and flow cytometry. These pH probes are cell-permeable, selectively label lysosomes, and can be used for noninvasive monitoring of lysosomal pH changes during physiological and pathological processes.
摘要
新的基于 BODIPY 的 pH 探针具有适合荧光显微镜和流式细胞术的激发和发射波长。这些 pH 探针可穿透细胞膜，选择性标记溶酶体，并可用于在生理和病理过程中非侵入性监测溶酶体 pH 值变化。
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