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[关于胰高血糖素对碳水化合物代谢影响机制的当前理论]

[Current theories on the mechanism of the effect of glucagon on carbohydrate metabolism].

作者信息

Pavliuk P M

出版信息

Fiziol Zh (1978). 1990 Jan-Feb;36(1):113-21.

PMID:2157610
Abstract

Glucagon is considered for mechanisms of its action on the carbon metabolism, its significance in the complex polyhormonal regulation of the glucose synthesis and metabolism being studied. Glucagon exerts its effect on cells through specific receptors arranged on the plasma membrane, while its effect on the carbohydrate metabolism is mediated, mainly, by cAMP-dependent phosphorylation os some proteins participating in regulation of carbohydrate synthesis and metabolism including the proteins controlling expression of many genes. The glucagon effect on the level and efficiency of the action of insulin and some other hormones is an important link in the glucagon action on the carbohydrate metabolism.

摘要

人们正在研究胰高血糖素对碳代谢的作用机制,及其在葡萄糖合成与代谢复杂多激素调节中的意义。胰高血糖素通过位于质膜上的特异性受体对细胞发挥作用,而其对碳水化合物代谢的影响主要由一些参与碳水化合物合成与代谢调节的蛋白质的环磷酸腺苷(cAMP)依赖性磷酸化介导,这些蛋白质包括控制许多基因表达的蛋白质。胰高血糖素对胰岛素及其他一些激素作用水平和效率的影响是其对碳水化合物代谢作用的重要环节。

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