细胞黏附分子神经束蛋白稳定轴突起始段的轴突-轴突 GABA 能末梢。
The cell adhesion molecule neurofascin stabilizes axo-axonic GABAergic terminals at the axon initial segment.
机构信息
Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, 72770 Reutlingen, Germany.
出版信息
J Biol Chem. 2011 Jul 8;286(27):24385-93. doi: 10.1074/jbc.M110.212191. Epub 2011 May 16.
Abstract
Cell adhesion molecules regulate synapse formation and maintenance via transsynaptic contact stabilization involving both extracellular interactions and intracellular postsynaptic scaffold assembly. The cell adhesion molecule neurofascin is localized at the axon initial segment of granular cells in rat dentate gyrus, which is mainly targeted by chandelier cells. Lentiviral shRNA-mediated knockdown of neurofascin in adult rat brain indicates that neurofascin regulates the number and size of postsynaptic gephyrin scaffolds, the number of GABA(A) receptor clusters as well as presynaptic glutamate decarboxylase-positive terminals at the axon initial segment. By contrast, overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways.
摘要
细胞黏附分子通过涉及细胞外相互作用和细胞内突触后支架组装的跨突触接触稳定来调节突触的形成和维持。神经黏附分子神经束蛋白位于大鼠齿状回颗粒细胞的轴突起始段，主要被 Chandelier 细胞靶向。慢病毒 shRNA 介导的成年大鼠脑内神经束蛋白敲低表明，神经束蛋白调节突触后蛋白聚糖支架的数量和大小、GABA(A) 受体簇的数量以及轴突起始段的谷氨酸脱羧酶阳性末梢。相比之下，在海马神经元中过表达神经束蛋白会增加蛋白聚糖簇的大小，推测是通过刺激成纤维细胞生长因子受体 1 信号通路。
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