Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Genes Dev. 2011 May 15;25(10):997-1003. doi: 10.1101/gad.2054311.
Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.
染色质修饰酶被认为是胚胎干细胞正确分化为特定谱系(如神经元)的关键组成部分。最近,多梳蛋白家族蛋白在肌肉干细胞的特化和分化中的作用已被研究。在这篇观点文章中,我们回顾了 Juan 及其同事在《基因与发育》(Genes & Development)上发表的一项最近研究,探讨了多梳蛋白家族蛋白 Ezh2 在肌肉干细胞中的作用,并讨论了其对一般谱系限制的影响。