• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多梳蛋白介导的终末分化抑制：不想长大成为什么？

Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?

机构信息

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

出版信息

Genes Dev. 2011 May 15;25(10):997-1003. doi: 10.1101/gad.2054311.

DOI:10.1101/gad.2054311
PMID:21576260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3093125/
Abstract

Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.

摘要

染色质修饰酶被认为是胚胎干细胞正确分化为特定谱系（如神经元）的关键组成部分。最近，多梳蛋白家族蛋白在肌肉干细胞的特化和分化中的作用已被研究。在这篇观点文章中，我们回顾了 Juan 及其同事在《基因与发育》（Genes & Development）上发表的一项最近研究，探讨了多梳蛋白家族蛋白 Ezh2 在肌肉干细胞中的作用，并讨论了其对一般谱系限制的影响。

相似文献

1
Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?多梳蛋白介导的终末分化抑制：不想长大成为什么？
Genes Dev. 2011 May 15;25(10):997-1003. doi: 10.1101/gad.2054311.
2
Polycomb complexes repress developmental regulators in murine embryonic stem cells.多梳复合物在小鼠胚胎干细胞中抑制发育调节因子。
Nature. 2006 May 18;441(7091):349-53. doi: 10.1038/nature04733. Epub 2006 Apr 19.
3
Stem cells primed for action: polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells.准备行动的干细胞：多梳抑制复合物抑制胚胎干细胞中谱系特异性调节因子的表达。
Cell Cycle. 2006 Jul;5(13):1411-4. doi: 10.4161/cc.5.13.2927. Epub 2006 Jul 1.
4
The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.多梳抑制复合物基因产物 Ezh2 调控小鼠肝干细胞/祖细胞的增殖和分化。
J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.
5
Stem cells and cancer; the polycomb connection.干细胞与癌症；多梳蛋白关联
Cell. 2004 Aug 20;118(4):409-18. doi: 10.1016/j.cell.2004.08.005.
6
Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective.简要综述：多梳蛋白家族在发育和疾病中的作用：干细胞视角
Stem Cells. 2007 Oct;25(10):2498-510. doi: 10.1634/stemcells.2006-0608. Epub 2007 Jun 28.
7
Jarid2 and PRC2, partners in regulating gene expression.Jarid2 和 PRC2，调控基因表达的合作伙伴。
Genes Dev. 2010 Feb 15;24(4):368-80. doi: 10.1101/gad.1886410. Epub 2010 Feb 1.
8
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.多梳蛋白Ezh2甲基转移酶调节肌肉基因表达和骨骼肌分化。
Genes Dev. 2004 Nov 1;18(21):2627-38. doi: 10.1101/gad.1241904.
9
MyoR is expressed in nonmyogenic cells and can inhibit their differentiation.肌调节蛋白在非肌源性细胞中表达，并能抑制它们的分化。
Exp Cell Res. 2003 Sep 10;289(1):162-73. doi: 10.1016/s0014-4827(03)00252-0.
10
Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.HOX基因的过表达在尤因肉瘤中普遍存在，并且与发育转录程序的表观遗传调控改变有关。
Epigenetics. 2014 Dec;9(12):1613-25. doi: 10.4161/15592294.2014.988048.

引用本文的文献

1
Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene.代谢应激诱导的长非编码 RNA 转录调控有丝分裂酵母 fbp1 基因减数分裂 DNA 断裂的形成。
PLoS One. 2024 Jan 22;19(1):e0294191. doi: 10.1371/journal.pone.0294191. eCollection 2024.
2
The PRC2 complex directly regulates the cell cycle and controls proliferation in skeletal muscle.PRC2 复合物直接调节细胞周期并控制骨骼肌的增殖。
Cell Cycle. 2020 Sep;19(18):2373-2394. doi: 10.1080/15384101.2020.1806448. Epub 2020 Aug 20.
3
JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle.JARID2 和 PRC2 复合物调节骨骼肌中的细胞周期。
J Biol Chem. 2019 Dec 20;294(51):19451-19464. doi: 10.1074/jbc.RA119.010060. Epub 2019 Oct 2.
4
JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.JARID2 和 PRC2 复合物通过调节经典 Wnt 信号通路调节骨骼肌分化。
Epigenetics Chromatin. 2018 Aug 17;11(1):46. doi: 10.1186/s13072-018-0217-x.
5
Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1.胚胎期Ezh2对Six1的抑制作用丧失导致出生后视网膜变性
Sci Rep. 2016 Sep 28;6:33887. doi: 10.1038/srep33887.
6
Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation.Ezh2维持视网膜祖细胞的增殖、转录完整性以及晚期分化的时机。
Dev Biol. 2015 Jul 15;403(2):128-38. doi: 10.1016/j.ydbio.2015.05.010. Epub 2015 May 16.
7
Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs.跨越111个参考表观基因组的表观基因组足迹揭示了长链非编码RNA的组织特异性表观遗传调控。
Nat Commun. 2015 Feb 18;6:6370. doi: 10.1038/ncomms7370.
8
Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.胰腺内分泌细胞特化过程中基因组H3K27me3结构域的动态变化及EZH2的作用
EMBO J. 2014 Oct 1;33(19):2157-70. doi: 10.15252/embj.201488671. Epub 2014 Aug 8.
9
Interferon-γ resets muscle cell fate by stimulating the sequential recruitment of JARID2 and PRC2 to promoters to repress myogenesis.干扰素-γ 通过刺激 JARID2 和 PRC2 顺次募集到启动子上，抑制成肌生成，从而重置肌肉细胞命运。
Sci Signal. 2013 Dec 10;6(305):ra107. doi: 10.1126/scisignal.2004633.
10
The Scaffold attachment factor b1 (Safb1) regulates myogenic differentiation by facilitating the transition of myogenic gene chromatin from a repressed to an activated state.支架附着因子 b1（Safb1）通过促进成肌基因染色质从抑制状态向激活状态的转变来调节成肌分化。
Nucleic Acids Res. 2013 Jun;41(11):5704-16. doi: 10.1093/nar/gkt285. Epub 2013 Apr 22.

本文引用的文献

1
Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells.多梳抑制酶 EZH2 控制着骨骼肌干细胞的自我更新和转录特性。
Genes Dev. 2011 Apr 15;25(8):789-94. doi: 10.1101/gad.2027911.
2
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns.染色质可及性预先决定了糖皮质激素受体结合模式。
Nat Genet. 2011 Mar;43(3):264-8. doi: 10.1038/ng.759. Epub 2011 Jan 23.
3
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.肿瘤坏死因子/p38α/多梳抑制复合物信号通路作用于卫星细胞中的 Pax7 基因座将炎症与肌肉再生的表观遗传调控联系起来。
Cell Stem Cell. 2010 Oct 8;7(4):455-69. doi: 10.1016/j.stem.2010.08.013.
4
Dynamics of muscle fibre growth during postnatal mouse development.出生后小鼠发育过程中肌纤维生长的动力学
BMC Dev Biol. 2010 Feb 22;10:21. doi: 10.1186/1471-213X-10-21.
5
2-D structure of the A region of Xist RNA and its implication for PRC2 association.Xist RNA A 区域的 2-D 结构及其对 PRC2 结合的影响。
PLoS Biol. 2010 Jan;8(1):e1000276. doi: 10.1371/journal.pbio.1000276. Epub 2010 Jan 5.
6
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression.许多人类大型基因间非编码RNA与染色质修饰复合物相关联并影响基因表达。
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72. doi: 10.1073/pnas.0904715106. Epub 2009 Jul 1.
7
The timing of emergence of muscle progenitors is controlled by an FGF/ERK/SNAIL1 pathway.肌肉祖细胞出现的时间由FGF/ERK/SNAIL1信号通路控制。
Dev Biol. 2009 Sep 15;333(2):229-37. doi: 10.1016/j.ydbio.2009.05.544. Epub 2009 May 13.
8
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation.多能人类造血干细胞中的染色质特征表明了二价基因在分化过程中的命运。
Cell Stem Cell. 2009 Jan 9;4(1):80-93. doi: 10.1016/j.stem.2008.11.011.
9
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.Ezh1和Ezh2通过不同机制维持染色质的抑制状态。
Mol Cell. 2008 Nov 21;32(4):503-18. doi: 10.1016/j.molcel.2008.11.004.
10
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment.H2AZ在胚胎干细胞的多梳复合物靶基因中富集，并且对于细胞谱系定向分化是必需的。
Cell. 2008 Nov 14;135(4):649-61. doi: 10.1016/j.cell.2008.09.056. Epub 2008 Nov 6.