在资源匮乏地区降低后续妊娠期间的艾滋病毒传播率。
Reduced HIV transmission at subsequent pregnancy in a resource-poor setting.
作者信息
Gumbo Felicity Zvanyadza, Kandawasvika Gwendoline Quintoline, Duri Kerina, Mapingure Munyaradzi Paul, Kurewa Nyaradzai Edith, Nathoo Kusum, Rusakaniko Simbarashe, Chirenje Mike Zvavahera, Stray-Pedersen Babill
机构信息
Department of Paediatrics and Child Health, College of Health Sciences, University of Zimbabwe, P Bag A178, Avondale, Harare, Zimbabwe.
出版信息
Trop Doct. 2011 Jul;41(3):132-5. doi: 10.1258/td.2011.100458. Epub 2011 May 16.
Several studies indicate that HIV-infected women continue to have children. We set out to determine the trend in HIV transmission at subsequent pregnancies. From 2002-2003, pregnant women were enrolled in a single dose nevirapine-based Prevention of Mother-to-Child Transmission of HIV (PMTCT) programme. Six years later, women with subsequent children in this cohort were identified and their children's HIV status determined. From 330 identified HIV-infected mothers, 73 had second/subsequent children with HIV results. Of these, nine (12.3%, 95% confidence interval [CI]: 4.6-20.1%) children were HIV-infected. Of the 73 second children, 51 had older siblings who had been initially enrolled in the study with definitive HIV results with an infection rate of 17/51 (33.3%, 95% CI: 19.9-46.7). About 35% of the women had been on antiretroviral drugs. These results demonstrate lower subsequent HIV transmission rates in women on a national PMTCT programme in a resource-poor setting with the advent of antiretroviral therapy.
多项研究表明，感染艾滋病毒的女性仍在继续生育。我们着手确定后续妊娠中艾滋病毒传播的趋势。2002年至2003年，孕妇被纳入一项基于单剂量奈韦拉平的预防母婴传播艾滋病毒（PMTCT）项目。六年后，确定了该队列中有后续子女的女性，并确定了其子女的艾滋病毒感染状况。在330名已确定感染艾滋病毒的母亲中，73名有第二个或更多子女并获得了艾滋病毒检测结果。其中，9名（12.3%，95%置信区间[CI]：4.6 - 20.1%）儿童感染了艾滋病毒。在73名第二个孩子中，51名有年长的兄弟姐妹，这些年长的兄弟姐妹最初参与研究时获得了明确的艾滋病毒检测结果，感染率为17/51（33.3%，95%CI：19.9 - 46.7）。约35%的女性一直在接受抗逆转录病毒药物治疗。这些结果表明，在资源匮乏地区，随着抗逆转录病毒疗法的出现，全国性PMTCT项目中的女性后续艾滋病毒传播率有所降低。
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