Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece.
In Vivo. 2011 May-Jun;25(3):343-54.
The Kiss-1 gene encodes a secreted protein that is proteolytically cleaved to produce a number of structurally related peptides, with high interspecies conservation, globally termed kisspeptins. The original niche for the role of kisspeptin in human physiology is derived from cancer biology, with the loss of Kiss-1 expression being associated with poor prognosis in several malignancies. However, kisspeptin has recently emerged as a fundamental player in the field of reproductive biology. Genetic analysis of large consanguineous pedigrees by two independent groups led to the association of inactivating mutations of GPR54, the receptor which mediates kisspeptin action, with idiopathic hypogonadotropic hypogonadism. In the present paper the most salient aspects of the multifaceted role of kisspeptin in the reproductive system are reviewed, including the association of kisspeptin with the gonadal steroid feedback loop and the triggering of puberty onset.
Kiss-1 基因编码一种分泌蛋白，该蛋白经蛋白水解切割后产生多种结构相关的肽，具有高度种间保守性，在全球范围内被称为 kisspeptins。 kisspeptin 在人类生理学中的作用的原始功能源于癌症生物学，在几种恶性肿瘤中，Kiss-1 表达的丧失与预后不良相关。然而，kisspeptin 最近已成为生殖生物学领域的重要参与者。两个独立小组对大型近亲系的遗传分析导致了与 GPR54 失活突变的关联，GPR54 是介导 kisspeptin 作用的受体，与特发性促性腺激素低下性性腺功能减退症有关。本文综述了 kisspeptin 在生殖系统中的多方面作用的最显著方面，包括与性腺类固醇反馈回路的关联以及青春期开始的触发。
