Sachs David H
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA.
Arch Surg. 2011 May;146(5):501-5. doi: 10.1001/archsurg.2011.101.
Ever since the first demonstration that transplant tolerance can be induced in neonatal mice by injection of donor bone marrow cells shortly after birth, the establishment of tolerance for organ transplants has been a major goal in the field of transplantation immunology. Indeed, an understanding of tolerance has both theoretical and practical implications for transplantation: from a theoretical point of view, an understanding of tolerance is basic to the requirement for self-/nonself-discrimination in the immune system; from a practical point of view, the induction of tolerance could relieve patients from the need for long-term immunosuppressant medications, thereby avoiding the adverse effects and complications that are a major limitation to the success of clinical transplant at present.
自从首次证明在新生小鼠出生后不久注射供体骨髓细胞可诱导移植耐受以来，建立器官移植耐受性一直是移植免疫学领域的主要目标。事实上，对耐受性的理解对移植具有理论和实际意义：从理论角度来看，对耐受性的理解是免疫系统中自我/非自我识别需求的基础；从实际角度来看，诱导耐受性可以使患者无需长期服用免疫抑制剂，从而避免目前临床移植成功的主要限制因素——副作用和并发症。
