Terada L S, Leff J A, Guidot D N, Shibao G A, Repine J E
Department of Medicine, University of Colorado Health Sciences Center, Denver.
Inflammation. 1990 Apr;14(2):217-21. doi: 10.1007/BF00917460.
We found that addition of cationic metals inhibited flavin-catalyzed superoxide anion (O2-.) production in vitro. Inhibition of O2-. generation by metals appeared to relate to the ability of metal ions to chelate or complex with amine groups, altering their electronegativity. Metal inhibition of O2-. production has important implications for biological systems involving O2-. radical production, as well as for assays requiring the generation of O2-. in vitro.
