Pham Annette M, Greene Ryan M, Woolery-Lloyd Heather, Kaufman Joely, Grunebaum Lisa D
University of Miami Cosmetic Medicine and Research Institute, Miami, Florida, USA.
Arch Facial Plast Surg. 2011 May-Jun;13(3):203-10. doi: 10.1001/archfacial.2011.28.
To investigate the efficacy of 1550-nm (Fraxel SR1500 RE:Store; Solta Medical, Hayward, California) nonablative laser treatment of facial surgical scars.
In this prospective clinical study, a volunteer sample of 13 adults with Fitzpatrick skin types I to III and facial surgical scars with a postoperative duration longer than 6 months were enrolled. Subjects were treated once every 4 weeks for a total of 4 treatments. Initial settings for the 1550-nm nonablative laser were at energy level 40 mJ and treatment level 4 and were subsequently increased on each visit according to the patients' tolerance level. Using a previously validated Patient and Observer Scar Assessment Scale (POSAS), the study subject and an independent evaluator completed assessments of the scar at each visit.
According to the Friedman test on ratings across all occasions after the first treatment to the last evaluation, there was a statistically significant improvement in the patient's assessment of the color, stiffness, thickness, and irregularity of the scar but not for pain or itching. For the observer's ratings, there was a statistically significant improvement in pigmentation, thickness, relief, and pliability but not for vascularization.
Preliminary data suggest improved aesthetic results, demonstrating the potential use of fractional photothermolysis as a scar revision technique. Future studies with a longer follow-up period could elucidate the role of fractional photothermolysis in more permanent scar improvements.
探讨1550纳米(飞梭SR1500 RE:Store;索塔医疗公司,加利福尼亚州海沃德)非剥脱性激光治疗面部手术瘢痕的疗效。
在这项前瞻性临床研究中,招募了13名 Fitzpatrick皮肤分型为I至III型且面部手术瘢痕术后持续时间超过6个月的成年志愿者。受试者每4周接受一次治疗,共治疗4次。1550纳米非剥脱性激光的初始设置为能量水平40 mJ、治疗水平4,随后每次就诊时根据患者的耐受程度进行调整。使用先前验证过的患者和观察者瘢痕评估量表(POSAS),研究对象和一名独立评估者在每次就诊时对瘢痕进行评估。
根据对首次治疗后至最后一次评估期间所有情况的评分进行的Friedman检验,患者对瘢痕颜色、硬度、厚度和不规则度的评估有统计学意义上的显著改善,但疼痛或瘙痒方面无改善。对于观察者的评分,色素沉着、厚度、平整度和柔韧性有统计学意义上的显著改善,但血管化方面无改善。
初步数据表明美学效果有所改善,证明了分次光热解作为一种瘢痕修复技术的潜在用途。未来进行更长随访期的研究可能会阐明分次光热解在更持久改善瘢痕方面的作用。