Chua Sze-Hon, Ang Por, Khoo Lawrence S W, Goh Chee-Leok
National Skin Center, Singapore, Singapore.
Dermatol Surg. 2004 Oct;30(10):1287-91. doi: 10.1111/j.1524-4725.2004.30402.x.
There is presently little published data on the clinical effectiveness of nonablative lasers in the treatment of atrophic acne scars and the safety of their use in patients with darker skin types.
This study aims to determine the clinical effectiveness and safety of the nonablative 1450 nm diode laser with cryogen cooling spray in the treatment of facial atrophic acne scars in Type IV-V Asian skin.
This is a prospective non-comparative open study. 4 to 6 laser treatment sessions were performed on patients with atrophic acne scars. Final clinical assessment was performed 6 months after the last treatment.
57 patients were evaluated. Patient's self-assessment of scar improvement as compared with doctor's assessment was as follows: patients who completed 4 treatments (15.7% vs 6.6%), patients who completed 5 treatments (20% vs 7.9%) and patients those who completed 6 treatments (17.3% vs 5.0%). Main side effects were mild to moderate pain during the procedure, transient erythema, and hyperpigmentation which occurred in 39% of treated patients.
The nonablative 1450 nm diode laser may be effective in achieving mild to moderate gradual clinical improvement in the treatment of facial atrophic acne scars. The procedure is associated with minimal downtime and is safe for use in darker skin types IV and V.
目前关于非剥脱性激光治疗萎缩性痤疮瘢痕的临床疗效以及其在深色皮肤类型患者中使用安全性的已发表数据较少。
本研究旨在确定采用非剥脱性1450纳米二极管激光联合冷冻剂喷雾治疗IV - V型亚洲人面部萎缩性痤疮瘢痕的临床疗效和安全性。
这是一项前瞻性非对照开放性研究。对患有萎缩性痤疮瘢痕的患者进行4至6次激光治疗。在最后一次治疗6个月后进行最终临床评估。
共评估了57例患者。患者对瘢痕改善情况的自我评估与医生评估结果如下:完成4次治疗的患者(15.7%对6.6%)、完成5次治疗的患者(20%对7.9%)以及完成6次治疗的患者(17.3%对5.0%)。主要副作用为治疗过程中轻度至中度疼痛、短暂性红斑以及色素沉着,39%的接受治疗患者出现色素沉着。
非剥脱性1450纳米二极管激光在治疗面部萎缩性痤疮瘢痕方面可能有效实现轻度至中度的渐进性临床改善。该治疗方法恢复时间最短,对IV型和V型深色皮肤类型患者使用安全。