细胞因子和两性霉素B对巨噬细胞氧化爆发活性的体内激活作用。
In vivo activation of macrophage oxidative burst activity by cytokines and amphotericin B.
作者信息
Wolf J E, Massof S E
机构信息
Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
出版信息
Infect Immun. 1990 May;58(5):1296-300. doi: 10.1128/iai.58.5.1296-1300.1990.
Abstract
Alterations in macrophage oxidative burst activity following in vivo administration of recombinant murine gamma interferon (IFN-gamma), recombinant murine tumor necrosis factor alpha, and the antifungal antibiotic amphotericin B were investigated. Mice were given intraperitoneal injections of these agents alone and in combination, and the oxidative responses of their resident peritoneal macrophages to challenge with Histoplasma capsulatum or zymosan particles were measured 1 to 5 days later. Various degrees of enhanced oxidative burst activity were achieved following treatment with each agent. However, a synergistic response was observed only when mice were treated with the combination of recombinant murine IFN-gamma and amphotericin B. These results not only confirm the dual role of amphotericin as an antifungal agent and as an immunomodulator but also suggest that IFN-gamma may serve as a useful adjunct in the treatment of intracellular fungal infections.
摘要
研究了体内给予重组小鼠γ干扰素（IFN-γ）、重组小鼠肿瘤坏死因子α和抗真菌抗生素两性霉素B后巨噬细胞氧化爆发活性的变化。单独或联合腹腔注射这些药物给小鼠，1至5天后测量其驻留腹膜巨噬细胞对荚膜组织胞浆菌或酵母聚糖颗粒攻击的氧化反应。每种药物治疗后均实现了不同程度的氧化爆发活性增强。然而，仅当用重组小鼠IFN-γ和两性霉素B联合治疗小鼠时观察到协同反应。这些结果不仅证实了两性霉素作为抗真菌剂和免疫调节剂的双重作用，还表明IFN-γ可能作为治疗细胞内真菌感染的有用辅助药物。
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本文引用的文献
1
Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism.兔肺泡巨噬细胞中的杀菌阳离子蛋白：一种潜在的宿主防御机制。
Infect Immun. 1980 Oct;30(1):180-92. doi: 10.1128/iai.30.1.180-192.1980.
2
Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.体外暴露于胞壁酰二肽或脂多糖的巨噬细胞中超氧阴离子生成增加。
J Exp Med. 1980 Jan 1;151(1):101-14. doi: 10.1084/jem.151.1.101.
3
Lymphokine enhances oxygen-independent activity against intracellular pathogens.淋巴因子增强针对细胞内病原体的非氧依赖性活性。
J Exp Med. 1983 Jul 1;158(1):234-9. doi: 10.1084/jem.158.1.234.
4
Activation of macrophages by lymphokines: enhancement of phagosome-lysosome fusion and killing of Coccidioides immitis.淋巴因子对巨噬细胞的激活作用：增强吞噬体-溶酶体融合及对粗球孢子菌的杀伤作用
Infect Immun. 1983 Mar;39(3):1201-7. doi: 10.1128/iai.39.3.1201-1207.1983.
5
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.鉴定γ干扰素为激活人类巨噬细胞氧化代谢和抗菌活性的淋巴因子。
J Exp Med. 1983 Sep 1;158(3):670-89. doi: 10.1084/jem.158.3.670.
6
7
Antifungal agents useful in therapy of systemic fungal infections.可用于全身性真菌感染治疗的抗真菌药物。
Annu Rev Pharmacol Toxicol. 1983;23:303-30. doi: 10.1146/annurev.pa.23.040183.001511.
8
Macrophage oxygen-dependent antimicrobial activity. III. Enhanced oxidative metabolism as an expression of macrophage activation.巨噬细胞的氧依赖性抗菌活性。III. 作为巨噬细胞活化表现的增强的氧化代谢。
J Exp Med. 1980 Dec 1;152(6):1596-609. doi: 10.1084/jem.152.6.1596.
9
Fungal sterols and the mode of action of the polyene antibiotics.真菌甾醇与多烯抗生素的作用方式
Adv Appl Microbiol. 1974;17(0):109-34. doi: 10.1016/s0065-2164(08)70556-2.
10
In vitro effect of phagocyte cationic peptides on Coccidioides immitis.吞噬细胞阳离子肽对粗球孢子菌的体外作用
J Infect Dis. 1985 May;151(5):890-4. doi: 10.1093/infdis/151.5.890.
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