• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1-（4-氨基苯基）-3-[2-（三氟甲基）苯基]丙-2-烯-1-酮

1-(4-Amino-phen-yl)-3-[2-(trifluoro-meth-yl)phen-yl]prop-2-en-1-one.

作者信息

Peng Jing, Xu Huifen, Li Zhe, Zhang Yuyan, Wu Jianzhang

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 24;66(Pt 5):o1156-7. doi: 10.1107/S1600536810014169.

DOI:10.1107/S1600536810014169
PMID:21579201
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2979023/
Abstract

The title compound, C(16)H(12)F(3)NO, a derivative of biologically active chalcones, comprises two benzene rings and a central -CH=CH-C(=O)- unit. The dihedral angle between the two rings is 10.9 (1)° and the mol-ecule adopts an E configuration about the central olefinic bond. The crystal structure is stabilized by inter-molecular N-H⋯O and N-H⋯N hydrogen bonds.

摘要

标题化合物C(16)H(12)F(3)NO是具有生物活性的查耳酮的衍生物，由两个苯环和一个中心-CH=CH-C(=O)-单元组成。两个环之间的二面角为10.9 (1)°，分子围绕中心烯键采取E构型。晶体结构通过分子间的N-H⋯O和N-H⋯N氢键得以稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d383/2979023/964d97c125c7/e-66-o1156-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d383/2979023/964d97c125c7/e-66-o1156-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d383/2979023/964d97c125c7/e-66-o1156-fig1.jpg

相似文献

1
1-(4-Amino-phen-yl)-3-[2-(trifluoro-meth-yl)phen-yl]prop-2-en-1-one.1-（4-氨基苯基）-3-[2-（三氟甲基）苯基]丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 24;66(Pt 5):o1156-7. doi: 10.1107/S1600536810014169.
2
(E)-1-(2-Amino-phen-yl)-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.（E）-1-（2-氨基苯基）-3-（3,4,5-三甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Sep 1;67(Pt 9):o2485-6. doi: 10.1107/S1600536811033861. Epub 2011 Aug 27.
3
1-[(Bromo-meth-yl)(phen-yl)meth-ylene]-2-(2,4-dinitro-phen-yl)hydrazine.1-[(溴甲基)(苯基)亚甲基]-2-(2,4-二硝基苯基)肼
Acta Crystallogr Sect E Struct Rep Online. 2009 May 7;65(Pt 6):o1221-2. doi: 10.1107/S1600536809016225.
4
(E)-1-[2-Hy-droxy-4,6-bis-(meth-oxy-meth-oxy)phen-yl]-3-[3-meth-oxy-4-(meth-oxy-meth-oxy)phen-yl]prop-2-en-1-one.（E）-1-[2-羟基-4,6-双（甲氧基甲氧基）苯基]-3-[3-甲氧基-4-（甲氧基甲氧基）苯基]丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o2931. doi: 10.1107/S1600536811041213. Epub 2011 Oct 12.
5
(E)-1-(4-Amino-phen-yl)-3-(pyridin-3-yl)prop-2-en-1-one.（E）-1-（4-氨基苯基）-3-（吡啶-3-基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1770-1. doi: 10.1107/S1600536811023634. Epub 2011 Jun 22.
6
Crystal structures of three 1-[4-(4-bromo-but-oxy)-phen-yl] chalcone derivatives: ()-1-[4-(4-bromo-but-oxy)-phen-yl]-3-phenyl-prop-2-en-1-one, ()-1-[4-(4-bromo-but-oxy)-phen-yl]-3-(4-meth-oxy-phen-yl)prop-2-en-1-one and ()-1-[4-(4-bromo-but-oxy)-phen-yl]-3-(3,4-di-meth-oxy-phen-yl)prop-2-en-1-one.三种1-[4-(4-溴丁氧基)-苯基]查尔酮衍生物的晶体结构：（）-1-[4-(4-溴丁氧基)-苯基]-3-苯基-2-丙烯-1-酮、（）-1-[4-(4-溴丁氧基)-苯基]-3-(4-甲氧基苯基)丙烯-1-酮和（）-1-[4-(4-溴丁氧基)-苯基]-3-(3,4-二甲氧基苯基)丙烯-1-酮。
Acta Crystallogr E Crystallogr Commun. 2017 Jul 21;73(Pt 8):1232-1236. doi: 10.1107/S2056989017010052. eCollection 2017 Jul 1.
7
1-(4-Bromo-phen-yl)-3-(4-ethoxy-phen-yl)-prop-2-en-1-one.1-（4-溴苯基）-3-（4-乙氧基苯基）-丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2008 Jul 19;64(Pt 8):o1540-1. doi: 10.1107/S1600536808021776.
8
(E)-3-(3-Chloro-phen-yl)-1-(4-methoxy-phen-yl)prop-2-en-1-one.（E）-3-（3-氯苯基）-1-（4-甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2010 May 15;66(Pt 6):o1346-7. doi: 10.1107/S1600536810017150.
9
2-{(E)-[(3-Iodo-4-methyl-phen-yl)imino]-meth-yl}-4-(trifluoro-meth-oxy)phenol.2-{(E)-[(3-碘-4-甲基苯基)亚氨基]甲基}-4-(三氟甲氧基)苯酚
Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2148. doi: 10.1107/S1600536812026876. Epub 2012 Jun 20.
10
(E)-3-(2-Chloro-phen-yl)-1-(4-chloro-phen-yl)prop-2-en-1-one.（E）-3-（2-氯苯基）-1-（4-氯苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2008 May 30;64(Pt 6):o1177. doi: 10.1107/S1600536808015420.

引用本文的文献

1
(E)-3-(3,4-Di-fluoro-phen-yl)-1-(3,4-di-meth-oxy-phen-yl)prop-2-en-1-one.（E）-3-（3,4-二氟苯基）-1-（3,4-二甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2013 May 25;69(Pt 6):o960. doi: 10.1107/S1600536813013767. Print 2013 Jun 1.
2
(E)-3-(2-Bromo-phen-yl)-1-(3,4-dimeth-oxy-phen-yl)prop-2-en-1-one.（E）-3-（2-溴苯基）-1-（3,4-二甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o776. doi: 10.1107/S1600536812006046. Epub 2012 Feb 17.
3
(E)-3-(2,4-Dimeth-oxy-phen-yl)-1-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.

本文引用的文献

1
(E)-1-(2-Thien-yl)-3-(3,4,5-trimethoxy-phen-yl)prop-2-en-1-one.
Acta Crystallogr Sect E Struct Rep Online. 2009 Jun 13;65(Pt 7):o1575-6. doi: 10.1107/S1600536809021850.
2
1-Phenyl-3-(2,4,6-trimethoxy-phen-yl)prop-2-en-1-one.1-苯基-3-(2,4,6-三甲氧基苯基)丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 23;65(Pt 11):o2805. doi: 10.1107/S1600536809041877.
3
Synthesis of mono-carbonyl analogues of curcumin and their effects on inhibition of cytokine release in LPS-stimulated RAW 264.7 macrophages.姜黄素单羰基类似物的合成及其对 LPS 刺激的 RAW 264.7 巨噬细胞细胞因子释放抑制作用的影响。
（E）-3-（2,4-二甲氧基苯基）-1-（3,4,5-三甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Jan;68(Pt 1):o154. doi: 10.1107/S1600536811053001. Epub 2011 Dec 17.
4
(E)-1-(4-Meth-oxy-phen-yl)-3-(2,4,6-trimeth-oxy-phen-yl)prop-2-en-1-one.（E）-1-（4-甲氧基苯基）-3-（2,4,6-三甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1432. doi: 10.1107/S1600536811017788. Epub 2011 May 14.
5
(E)-3-(2,4-Dimeth-oxy-phen-yl)-1-(3,4-dimeth-oxy-phen-yl)prop-2-en-1-one.
Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 31;66(Pt 11):o3015. doi: 10.1107/S1600536810043606.
6
(E)-1-(3,5-Difluoro-phen-yl)-3-(2,4-dimeth-oxy-phen-yl)prop-2-en-1-one.（E）-1-（3,5-二氟苯基）-3-（2,4-二甲氧基苯基）丙-2-烯-1-酮
Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 8;66(Pt 10):o2518. doi: 10.1107/S1600536810035257.
Bioorg Med Chem. 2010 Apr 1;18(7):2388-93. doi: 10.1016/j.bmc.2010.03.001. Epub 2010 Mar 6.
4
Study of the anti-inflammatory and analgesic effects of novel rigid benzofuran-3, 4-dihydroxy chalcone by formalin, hot-plate and carrageenan tests in mice.通过福尔马林、热板和角叉菜胶试验对新型刚性苯并呋喃-3,4-二羟基查尔酮在小鼠体内的抗炎和镇痛作用进行研究。
Pak J Pharm Sci. 2009 Oct;22(4):395-401.
5
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.探索与合成在体外和体内均具有改善的结构稳定性的姜黄素类似物作为细胞毒性剂。
Bioorg Med Chem. 2009 Mar 15;17(6):2623-31. doi: 10.1016/j.bmc.2008.10.044. Epub 2008 Nov 1.
6
Antiangiogenic effects of flavonoids and chalcones.黄酮类化合物和查耳酮的抗血管生成作用。
Pharmacol Res. 2008 Apr;57(4):259-65. doi: 10.1016/j.phrs.2008.02.005. Epub 2008 Feb 23.
7
Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity.新型吡咯并苯二氮卓-查耳酮缀合物的固相合成：DNA结合亲和力和抗癌活性。
Bioorg Med Chem Lett. 2008 Apr 1;18(7):2434-9. doi: 10.1016/j.bmcl.2008.02.047. Epub 2008 Mar 5.
8
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
9
Total synthesis of munchiwarin, a triprenylated chalcone from Crotalaria medicagenia.
Org Lett. 2007 Dec 20;9(26):5369-72. doi: 10.1021/ol702187m. Epub 2007 Nov 22.
10
A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.一种硼酸查尔酮衍生物通过抑制蛋白酶体表现出强大的抗癌活性。
Mol Pharmacol. 2006 Jul;70(1):426-33. doi: 10.1124/mol.105.021311. Epub 2006 Apr 24.