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R-2，C-6-双（4-氯苯基）-C-3，T-3-二甲基哌啶-4-酮

r-2,c-6-Bis(4-chloro-phen-yl)-c-3,t-3-dimethyl-piperidin-4-one.

作者信息

Ilango S S, Ponnuswamy S, Gayathri P, Thiruvalluvar A, Butcher R J

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Nov 13;64(Pt 12):o2312. doi: 10.1107/S1600536808036325.

DOI:10.1107/S1600536808036325
PMID:21581289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2960012/
Abstract

In the title mol-ecule, C(19)H(19)Cl(2)NO, the piperidine ring adopts a chair conformation and the dihedral angle between the two benzene rings is 77.23 (7)°. In the crystal structure, mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds, and a weak C-H⋯π inter-action is also observed.

摘要

在标题分子C(19)H(19)Cl(2)NO中，哌啶环呈椅式构象，两个苯环之间的二面角为77.23 (7)°。在晶体结构中，分子通过N-H⋯O和C-H⋯O氢键相连，并且还观察到一个弱的C-H⋯π相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7324/2960012/543631031fcc/e-64-o2312-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7324/2960012/b544402e2c40/e-64-o2312-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7324/2960012/543631031fcc/e-64-o2312-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7324/2960012/b544402e2c40/e-64-o2312-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7324/2960012/543631031fcc/e-64-o2312-fig2.jpg

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本文引用的文献

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A short history of SHELX.SHELX简史。
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The preparation of some piperidine derivatives by the Mannich reaction.通过曼尼希反应制备某些哌啶衍生物。
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J Am Chem Soc. 1948 Nov;70(11):3853-5. doi: 10.1021/ja01191a092.
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J Med Chem. 2001 Feb 15;44(4):586-93. doi: 10.1021/jm0002580.