大剂量1α-羟基维生素D3长期治疗对Ⅱ型维生素D依赖性佝偻病患者钙磷平衡的影响。

Effect of long-term treatment with massive doses of 1 alpha-hydroxyvitamin D3 on calcium-phosphate balance in patients with vitamin D-dependent rickets type II.

作者信息

Takeda E, Yokota I, Saijo T, Kawakami I, Ito M, Kuroda Y

机构信息

Department of Pediatrics, School of Medicine, University of Tokushima, Japan.

出版信息

Acta Paediatr Jpn. 1990 Feb;32(1):39-43. doi: 10.1111/j.1442-200x.1990.tb00782.x.

DOI:10.1111/j.1442-200x.1990.tb00782.x

PMID:2158205

Abstract

Three patients with vitamin D-dependent rickets type II were given massive doses of 1 alpha-hydroxyvitamin D3 for 29 to 36 months and their calcium-phosphate balance was studied during treatment and one month after cessation of treatment. During treatment fasting hypercalciuria was observed in patient 1 and an increased rate of calcium excretion after calcium loading in patients 1 and 2. In these patients, calcium excretion was parallel with the serum 24,25-dihydroxyvitamin D concentration, which may reflect the level of receptor for 1,25-dihydroxyvitamin D. These findings suggested that the responsiveness to 1,25-dihydroxyvitamin D improved during long-term treatment of these two patients with vitamin D-dependent rickets type II.

摘要

三名II型维生素D依赖性佝偻病患者接受了大剂量的1α-羟维生素D3治疗，疗程为29至36个月，并在治疗期间及停止治疗后1个月对其钙磷平衡进行了研究。治疗期间，患者1出现空腹高钙尿症，患者1和2在钙负荷后钙排泄率增加。在这些患者中，钙排泄与血清24,25-二羟维生素D浓度平行，这可能反映了1,25-二羟维生素D受体的水平。这些发现表明，在对这两名II型维生素D依赖性佝偻病患者进行长期治疗期间，其对1,25-二羟维生素D的反应性有所改善。