Muraki K, Nishi Y, Tsuda K, Yoshimitsu K, Usui T
Acta Paediatr Scand. 1983 Sep;72(5):763-8. doi: 10.1111/j.1651-2227.1983.tb09809.x.
A 1 5/12-year-old girl with hypophosphataemic vitamin D-resistant rickets was treated with initial massive doses of 1 alpha-hydroxy-vitamin D3 (1 alpha-OH-D3) alone. A dramatic improvement of bone lesions and growth rate and normalization of the characteristic biochemical defects were noted within four months after the start of massive 1 alpha-OH-D3 therapy. The results of this study suggest that early therapy with massive doses of 1 alpha-OH-D3 alone improves the radiological findings and restores to normal the biochemical defects and the growth rate as early as possible. This regimen may improve motor strength and endurance and obviate the need for corrective orthopaedic procedures.
一名患有低磷性维生素D抵抗性佝偻病的15/12岁女孩，最初仅接受大剂量的1α-羟基维生素D3（1α-OH-D3）治疗。在开始大剂量1α-OH-D3治疗后的四个月内，观察到骨病变和生长速率显著改善，特征性生化缺陷恢复正常。本研究结果表明，早期单独使用大剂量1α-OH-D3治疗可改善放射学表现，并尽早使生化缺陷和生长速率恢复正常。该治疗方案可能会提高运动强度和耐力，并避免进行矫正性骨科手术。
