Low R B, Leslie K O, Hemenway D R, Absher M, Adler K B, Giancola M S, Vacek P M
Department of Physiology and Biophysics, University of Vermont, Burlington 05405.
Am J Pathol. 1990 Apr;136(4):923-31.
Alpha-cristobalite causes pulmonary interstitial disease in humans and experimental animals. Aerosol exposure of rats to cristobalite for 8 days results in early and sustained alveolar type II cell hyperplasia in areas of inflammation characterized by the presence of macrophages and polymorphonuclear leukocytes. Irregular interstitial fibrosis and coalescence of alveoli are apparent by day 120. The inflammatory response is characterized by increased lavage cell recoveries, principally macrophages and neutrophils. Lavage recoveries of protein, nonpolar lipid, phospholipid, and saturated phosphatidylcholine also are increased. The recovery ratio for two important surfactant phospholipids, phosphatidylcholine and phosphatidylglycerol, is decreased at all points following exposure. Our morphologic analyses, together with results correlating lavage cell and lipid recoveries, point to the potential importance of macrophages and neutrophils in the epithelial cell response to cristobalite exposure.
α-方石英可导致人类和实验动物发生肺间质疾病。将大鼠暴露于方石英气溶胶中8天，会在以巨噬细胞和多形核白细胞存在为特征的炎症区域导致早期且持续的II型肺泡细胞增生。到第120天时，不规则的间质纤维化和肺泡融合明显可见。炎症反应的特征是灌洗细胞回收率增加，主要是巨噬细胞和中性粒细胞。灌洗回收的蛋白质、非极性脂质、磷脂和饱和磷脂酰胆碱也增加。暴露后所有时间点，两种重要的表面活性剂磷脂，即磷脂酰胆碱和磷脂酰甘油的回收率均降低。我们的形态学分析以及灌洗细胞与脂质回收率相关的结果表明，巨噬细胞和中性粒细胞在上皮细胞对方石英暴露的反应中可能具有重要作用。
