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水平流吸入毒理学设施的设计、开发与测试结果

Design, development and test results of a horizontal flow inhalation toxicology facility.

作者信息

Hemenway D R, MacAskill S M

出版信息

Am Ind Hyg Assoc J. 1982 Dec;43(12):874-9. doi: 10.1080/15298668291410738.

DOI:10.1080/15298668291410738
PMID:7158602
Abstract

A horizontal flow chamber was developed for the purposes of conducting inhalation toxicology research. The chamber utilizes a unique diffuser system and pre-mixing of contaminants to achieve uniform exposure. The use of fecal catch pans eliminates exposure of animals to fecal debris from overhead animals. The chamber performance shows a rapid equilibrium in startup and shutdown.

摘要

为了进行吸入毒理学研究,开发了一种水平流动室。该室采用独特的扩散器系统和污染物预混合技术,以实现均匀暴露。使用粪便收集盘可避免动物接触上方动物的粪便碎片。该室的性能表明,其启动和关闭时能迅速达到平衡。

相似文献

1
Design, development and test results of a horizontal flow inhalation toxicology facility.水平流吸入毒理学设施的设计、开发与测试结果
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[Chamber for the inhalational exposure of animals].[动物吸入暴露舱]
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Effectiveness of animal rotation in achieving uniform dust exposures and lung dust deposition in horizontal flow chambers.动物轮换在水平流动舱中实现均匀粉尘暴露和肺内粉尘沉积的有效性。
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[Method of preparing a simple exposure chamber for toxicology research].[一种用于毒理学研究的简易暴露室的制备方法]
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Development and use of a single-animal whole-body system for inhalation exposure.用于吸入暴露的单动物全身系统的开发与应用。
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Increased phosphorylated extracellular signal-regulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice.在小鼠吸入温石棉后,磷酸化细胞外信号调节激酶免疫反应性增加,与肺的增殖和形态学改变相关。
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Pleural macrophage recruitment and activation in asbestos-induced pleural injury.
石棉诱导的胸膜损伤中胸膜巨噬细胞的募集与激活
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Biphasic cellular and tissue response of rat lungs after eight-day aerosol exposure to the silicon dioxide cristobalite.大鼠肺部在气溶胶暴露于方石英型二氧化硅八天后的双相细胞和组织反应。
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Alveolar type II cell response in rats exposed to aerosols of alpha-cristobalite.暴露于α-方石英气溶胶的大鼠的II型肺泡细胞反应。
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Increased manganese superoxide dismutase protein in type II epithelial cells of rat lungs after inhalation of crocidolite asbestos or cristobalite silica.吸入青石棉或方石英后大鼠肺Ⅱ型上皮细胞中锰超氧化物歧化酶蛋白增加。
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