(9S,13R,14R)-7,8-二脱氢-3,4,7-三甲氧基-17-甲基吗啡喃-6-酮
(9S,13R,14R)-7,8-Didehydro-3,4,7-trimeth-oxy-17-methyl-morphinan-6-one.
作者信息
Li Yu-Feng, Qian Yi, Yin Li-He, Lv Ran, Zhu Hong-Jun
机构信息
Department of Applied Chemistry, College of Science, Nanjing University of Technology, Nanjing 210009, People's Republic of China.
出版信息
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 6;65(Pt 4):o689. doi: 10.1107/S1600536808040749.
Abstract
The title compound, C(20)H(25)NO(4), was synthesized by a Mitsunobu reaction of sinomenine [(9S,13R,14R)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one] with methanol. The chiral centers were unchanged during the reaction. Intra-molecular C-H⋯O hydrogen bonds result in the formation of six-membered rings.
摘要
标题化合物C(20)H(25)NO(4)是通过青藤碱[(9S,13R,14R)-7,8-二脱氢-4-羟基-3,7-二甲氧基-17-甲基吗啡喃-6-酮]与甲醇的 Mitsunobu 反应合成的。反应过程中手性中心未发生变化。分子内C-H⋯O氢键导致形成六元环。
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