Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.
作者信息
Gootz T D, Barrett J F, Sutcliffe J A
机构信息
Department of Immunology and Infectious Diseases, Pfizer Central Research, Groton, Connecticut 06340.
出版信息
Antimicrob Agents Chemother. 1990 Jan;34(1):8-12. doi: 10.1128/AAC.34.1.8.
Abstract
摘要
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Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo- in vitro assay for potential carcinogens and mutagens.从经基因毒性剂处理的大鼠分离的肝细胞中检测非程序性DNA合成：一种针对潜在致癌物和诱变剂的体内-体外检测方法。
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Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases.萘啶酸、恶喹酸和新生霉素可抑制酵母甘氨酰 - 和亮氨酰 - 转移RNA合成酶。
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Quinolone antibiotics inhibit eucaryotic DNA polymerase alpha and beta, terminal deoxynucleotidyl transferase but not DNA ligase.喹诺酮类抗生素可抑制真核生物DNA聚合酶α和β、末端脱氧核苷酸转移酶，但不抑制DNA连接酶。
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Revised methods for the Salmonella mutagenicity test.沙门氏菌致突变性试验的修订方法。
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The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria.细菌DNA促旋酶抑制剂对哺乳动物线粒体中DNA合成的影响。
Biochim Biophys Acta. 1983 Sep 9;740(4):417-27. doi: 10.1016/0167-4781(83)90090-8.
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DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.来自黑腹果蝇的DNA拓扑异构酶II。超螺旋DNA的松弛
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DNA topoisomerases from rat liver: physiological variations.大鼠肝脏中的DNA拓扑异构酶：生理变异
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A homogeneous type II DNA topoisomerase from HeLa cell nuclei.一种来自HeLa细胞核的均一性II型DNA拓扑异构酶。
J Biol Chem. 1981 Sep 10;256(17):9334-9.
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Cell. 1980 Aug;21(1):115-25. doi: 10.1016/0092-8674(80)90119-1.
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