• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

萘啶酸、恶喹酸和新生霉素可抑制酵母甘氨酰 - 和亮氨酰 - 转移RNA合成酶。

Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases.

作者信息

Wright H T, Nurse K C, Goldstein D J

出版信息

Science. 1981 Jul 24;213(4506):455-6. doi: 10.1126/science.7017932.

DOI:10.1126/science.7017932
PMID:7017932
Abstract

Nalidixic acid and novobiocin inhibit the aminoacylation and pyrophosphate exchange activities of glycyl- and leucyl-transfer RNA synthetases from bakers' yeast. Similar types of inhibition are observed for both enzymes, suggesting similar mechanisms. The potency of these inhibitors is comparable to that observed for their inhibition of in vivo DNA synthesis in eukaryotic cells.

摘要

萘啶酸和新生霉素可抑制来自面包酵母的甘氨酰 - 和亮氨酰 - 转移RNA合成酶的氨酰化和焦磷酸交换活性。两种酶都观察到类似类型的抑制作用，表明机制相似。这些抑制剂的效力与其对真核细胞体内DNA合成的抑制作用相当。

相似文献

1
Nalidixic acid, oxolinic acid, and novobiocin inhibit yeast glycyl- and leucyl-transfer RNA synthetases.萘啶酸、恶喹酸和新生霉素可抑制酵母甘氨酰 - 和亮氨酰 - 转移RNA合成酶。
Science. 1981 Jul 24;213(4506):455-6. doi: 10.1126/science.7017932.
2
Effect of the bacterial DNA gyrase inhibitors, novobiocin, nalidixic acid, and oxolinic acid, on oxidative phosphorylation.细菌DNA促旋酶抑制剂新生霉素、萘啶酸和恶喹酸对氧化磷酸化的影响。
J Biol Chem. 1986 Jul 5;261(19):8604-7.
3
Pyrophosphate-caused inhibition of the aminoacylation of tRNA by the leucyl-tRNA synthetase from Neurospora crassa.焦磷酸对粗糙脉孢菌亮氨酰 - tRNA合成酶催化的tRNA氨酰化作用的抑制
Eur J Biochem. 1986 Oct 15;160(2):291-6. doi: 10.1111/j.1432-1033.1986.tb09970.x.
4
Isolation of a single polypeptide leucyl-tRNA synthetase from bakers' yeast.从面包酵母中分离出单一多肽的亮氨酰 - tRNA合成酶。
Nucleic Acids Res. 1979 Aug 10;6(11):3651-60. doi: 10.1093/nar/6.11.3651.
5
Kinetic studies of leucyl transfer RNA synthetase from bakers' yeast. Order of addition of substrates and release of products.面包酵母亮氨酰转移核糖核酸合成酶的动力学研究。底物添加顺序和产物释放情况。
J Biol Chem. 1975 Dec 25;250(24):9299-303.
6
[Sulfhydryl groups of leucyl-tRNA synthetase from the cow mammary gland].
Ukr Biokhim Zh (1978). 1982 May-Jun;54(3):322-5.
7
Purification and some properties of alanyl- and leucyl-tRNA synthetases from baker's yeast.面包酵母丙氨酰 - 转运RNA合成酶和亮氨酰 - 转运RNA合成酶的纯化及某些特性
Biochim Biophys Acta. 1981 Mar 26;653(1):83-90. doi: 10.1016/0005-2787(81)90106-4.
8
Inhibition of leucyl-transfer ribonucleic acid synthetasymol.亮氨酰转移核糖核酸合成酶的抑制作用
Biochem J. 1975 Dec;152(3):511-5. doi: 10.1042/bj1520511.
9
Escherichia coli DNA synthesis in vitro: insensitivity of ATP-dependent DNA repair to inhibition by novobiocin.体外大肠杆菌DNA合成：ATP依赖的DNA修复对新生霉素抑制的不敏感性。
Nucleic Acids Res. 1977 Jun;4(6):2057-64. doi: 10.1093/nar/4.6.2057.
10
Novobiocin inhibits Xenopus transcription factor IIIA-DNA interactions.新生霉素抑制非洲爪蟾转录因子IIIA与DNA的相互作用。
J Biol Chem. 1987 Sep 5;262(25):11916-9.

引用本文的文献

1
Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An Analysis.基于喹啉的SARS-CoV-2 3CL蛋白酶和RNA依赖性RNA聚合酶抑制剂以及刺突受体结合结构域-血管紧张素转换酶2抑制剂用于抗COVID-19的药物再利用分析
Front Microbiol. 2020 Jul 23;11:1796. doi: 10.3389/fmicb.2020.01796. eCollection 2020.
2
Adenovirus cores can function as templates in in vitro DNA replication.腺病毒核心可作为体外DNA复制的模板。
EMBO J. 1983;2(3):339-44. doi: 10.1002/j.1460-2075.1983.tb01428.x.
3
Rapid reversible changes in the rate of histone gene transcription and histone mRNA levels in mouse myeloma cells.小鼠骨髓瘤细胞中组蛋白基因转录速率和组蛋白mRNA水平的快速可逆变化。
Mol Cell Biol. 1984 Feb;4(2):351-7. doi: 10.1128/mcb.4.2.351-357.1984.
4
Cinoxacin. A review of its pharmacological properties and therapeutic efficacy in the treatment of urinary tract infections.西诺沙星。其药理学特性及治疗尿路感染疗效的综述。
Drugs. 1983 Jun;25(6):544-69. doi: 10.2165/00003495-198325060-00002.
5
Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states.生理和病理状态下的高等真核生物氨酰-tRNA合成酶
Mol Cell Biochem. 1986 Aug;71(2):107-20. doi: 10.1007/BF00214769.
6
Novobiocin antagonism of amastigotes of Trypanosoma cruzi growing in cell-free medium.新生霉素对在无细胞培养基中生长的克氏锥虫无鞭毛体的拮抗作用。
Antimicrob Agents Chemother. 1986 Mar;29(3):426-31. doi: 10.1128/AAC.29.3.426.
7
Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts.4-喹诺酮类药物和新生霉素对小牛胸腺DNA聚合酶α引发酶复合物、拓扑异构酶I和II以及哺乳动物淋巴母细胞生长的影响。
Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8. doi: 10.1128/AAC.29.6.1073.
8
Novobiocin inhibits RNA polymerase III transcription in vitro by a mechanism distinct from DNA topoisomerase II.新生霉素通过一种不同于DNA拓扑异构酶II的机制在体外抑制RNA聚合酶III转录。
Nucleic Acids Res. 1986 Mar 11;14(5):2075-88. doi: 10.1093/nar/14.5.2075.
9
Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.喹诺酮类抗菌剂对真核拓扑异构酶的抑制作用及相关测试系统
Antimicrob Agents Chemother. 1990 Jan;34(1):8-12. doi: 10.1128/AAC.34.1.8.
10
The effect of novobiocin on yeast topoisomerase type II.新生霉素对酵母II型拓扑异构酶的作用。
Mol Gen Genet. 1990 Jan;220(2):256-60. doi: 10.1007/BF00260491.