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(4S,5S)-2-(4-氯苯基)-1,3-二氧戊环-4,5-二甲酰胺

(4S,5S)-2-(4-Chloro-phen-yl)-1,3-dioxolane-4,5-dicarboxamide.

作者信息

Wang De-Cai, Bai Jing, Xu Wei, Gai Tao, Liu Hua-Quan

机构信息

School of Pharmaceutical Sciences, Nanjing University of Technology, Xinmofan Road No.5 Nanjing, Nanjing 210009, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Jul 22;65(Pt 8):o1960. doi: 10.1107/S1600536809027494.

DOI:10.1107/S1600536809027494
PMID:21583638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2977328/
Abstract

The title compound, C(11)H(11)ClN(2)O(4), is an important inter-mediate for the preparation of platinum anti-cancer drugs. The dioxolane ring adopts a twist conformation with an equatorially attached chloro-phenyl substituent. In the crystal structure, mol-ecules are linked into a two-dimensional network parallel to (001) by N-H⋯O and C-H⋯O hydrogen bonds.

摘要

标题化合物C(11)H(11)ClN(2)O(4)是制备铂类抗癌药物的重要中间体。二氧戊环环采取扭船式构象，氯苯基取代基位于赤道位置。在晶体结构中，分子通过N-H⋯O和C-H⋯O氢键连接成平行于(001)的二维网络。

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A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
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Synthesis and antitumor activity of a series of [2-substituted-4,5-bis(aminomethyl)-1,3-dioxolane]platinum(II) complexes.一系列[2-取代-4,5-双（氨甲基）-1,3-二氧戊环]铂（II）配合物的合成及其抗肿瘤活性
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