(4S,5S)-2-(2-噻吩基)-1,3-二氧戊环-4,5-二甲酰胺
(4S,5S)-2-(2-Thien-yl)-1,3-dioxolane-4,5-dicarboxamide.
作者信息
Xu Wei, Yang Zheng, Li Xin-Hua, Liu Bo-Nian, Wang De-Cai
出版信息
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 14;65(Pt 4):o764. doi: 10.1107/S1600536809008368.
In the title compound, C(9)H(10)N(2)O(4)S, which is an important inter-mediate for the preparation of anti-tumor platinum drugs, the dioxolane ring adopts an envelope conformation with the C atom bonded to the thienyl ring at the flap position. Intra-molecular N-H⋯O and C-H⋯O hydrogen bonds result in the formation of two five-membered rings having envelope conformations. In the crystal structure, inter-molecular N-H⋯O and C-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional network.
在标题化合物C₉H₁₀N₂O₄S中，它是制备抗肿瘤铂类药物的重要中间体，二氧戊环环采取信封式构象，其中与噻吩环相连的C原子处于折叶位置。分子内的N-H⋯O和C-H⋯O氢键导致形成两个具有信封式构象的五元环。在晶体结构中，分子间的N-H⋯O和C-H⋯O氢键将分子连接成三维网络。
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