Butterfield D A, Braden M L, Markesbery W R
J Supramol Struct. 1978;9(1):125-30. doi: 10.1002/jss.400090112.
The interaction of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with erythrocyte membranes from patients with Huntington disease and normal controls has been studied by electron spin resonance. GABA affects the physical state of erythrocyte membrane proteins in control and Huntington disease differently. In addition, after exposure of spin-labeled Huntington disease erythrocyte membranes to 0.1 mM GABA, the relevant electron spin resonance parameters reflecting the physical state of membrane proteins are indistinguishable from those of untreated control membranes. These findings support the concept that this disease is associated with a generalized membrane defect.
通过电子自旋共振研究了抑制性神经递质γ-氨基丁酸（GABA）与亨廷顿病患者及正常对照者红细胞膜的相互作用。GABA对正常对照者和亨廷顿病患者红细胞膜蛋白的物理状态有不同影响。此外，将自旋标记的亨廷顿病患者红细胞膜暴露于0.1 mM GABA后，反映膜蛋白物理状态的相关电子自旋共振参数与未处理的对照膜无法区分。这些发现支持了该疾病与普遍存在的膜缺陷相关的概念。
