Butterfield D A, Markesbery W R
Neurosci Lett. 1983 Feb 21;35(2):221-6. doi: 10.1016/0304-3940(83)90554-2.
Previous electron spin resonance (ESR) studies employing a protein-specific spin label have suggested an alteration in membrane proteins in erythrocytes in Huntington's disease (HD). Recently, Beverstock and Pearson [4] have published the results of an ESR study not confirming our findings. In the present communication, we show that with correct use of the statistical technique of the Dixon test to determine if extreme values can be eliminated, one of the data points of these authors can be rejected. Recalculation of their results suggests a significant difference in the physical state of membrane proteins in HD erythrocytes, confirming our findings.
先前采用蛋白质特异性自旋标记的电子自旋共振（ESR）研究表明，亨廷顿舞蹈症（HD）患者红细胞中的膜蛋白发生了改变。最近，贝弗斯托克和皮尔森[4]发表了一项ESR研究结果，未证实我们的发现。在本通讯中，我们表明，正确使用狄克逊检验的统计技术来确定是否可以剔除极端值后，这些作者的一个数据点可以被拒绝。重新计算他们的结果表明，HD患者红细胞中膜蛋白的物理状态存在显著差异，证实了我们的发现。
